About   Help   FAQ
Klhl22 Gene Detail
Summary
  • Symbol
    Klhl22
  • Name
    kelch-like 22
  • Synonyms
    2610318I18Rik, Kelchl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1337995
    NCBI Gene: 224023
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:17577485-17611246 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 11.01 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1337995
 protein coding gene Chr16:17577482-17611246 (+)
129S1/SvImJ ENSMUSG00200040840
 protein coding gene Chr16:14574052-14607817 (+)
A/J ENSMUSG00195031064
 protein coding gene Chr16:14131348-14165109 (+)
AKR/J ENSMUSG00220044487
 protein coding gene Chr16:14447605-14481371 (+)
BALB/cJ ENSMUSG00180029966
 protein coding gene Chr16:14372585-14406347 (+)
C3H/HeJ ENSMUSG00175048464
 protein coding gene Chr16:14517592-14551357 (+)
C57BL/6NJ ENSMUSG00215041056
 protein coding gene Chr16:14238697-14272463 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020525
 protein coding gene Chr16:14250616-14285628 (+)
CAST/EiJ ENSTCUG00005042230
 protein coding gene Chr16:14457117-14491032 (+)
CBA/J ENSMUSG00210046255
 protein coding gene Chr16:14533910-14567675 (+)
DBA/2J ENSMUSG00185029150
 protein coding gene Chr16:14480072-14513841 (+)
FVB/NJ ENSMUSG00205036890
 protein coding gene Chr16:14487690-14521457 (+)
JF1/MsJ ENSUMUG00000050757
 protein coding gene Chr16:14563615-14597956 (+)
LP/J ENSMUSG00230040681
 protein coding gene Chr16:17057941-17091705 (+)
NOD/ShiLtJ ENSMUSG00190031243
 protein coding gene Chr16:14619958-14653720 (+)
NZO/HlLtJ ENSMUSG00225030509
 protein coding gene Chr16:20303773-20337533 (+)
PWK/PhJ ENSLUMG00010036315
 protein coding gene Chr16:14445287-14479104 (+)
SPRET/EiJ ENSMSPG00010041183
 protein coding gene Chr16:14462833-14496789 (+)
WSB/EiJ ENSIUOG00005037258
 protein coding gene Chr16:14614043-14647786 (+)



Homology
more
  • Human Ortholog
    KLHL22, kelch like family member 22
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLHL22, kelch like family member 22
  • Synonyms
    KELCHL
  • Links
    NCBI Gene ID: 84861
    UniProt: Q53GT1

  • Chr Location
    22q11.21; chr22:20441519-20496893 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased growth of implanted tumor cells with reduced survival and Cd4+ and CD8+ T cells expressing IFNgamma, TNF, and granzyme B.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    98
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    95
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 224023 NCBI Gene Model | MGI Sequence Detail 33762 C57BL/6J ±  kb
    transcript NM_001379026 RefSeq | MGI Sequence Detail 5687 ZRU/MplStud  
    polypeptide Q99JN2 UniProt | EBI | MGI Sequence Detail 634 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      Genomic 5
      cDNA 96

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1919759
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:20131 Kerr SM, et al., Analysis of cDNA sequences from mouse testis. Mamm Genome. 1994 Sep;5(9):557-65
    • Latest
      J:359574 Eom TY, et al., Tbx1 haploinsufficiency leads to local skull deformity, paraflocculus and flocculus dysplasia, and motor-learning deficit in 22q11.2 deletion syndrome. Nat Commun. 2024 Dec 5;15(1):10510
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory