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Angpt4 Gene Detail
Summary
  • Symbol
    Angpt4
  • Name
    angiopoietin 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336887
    NCBI Gene: 11602
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:151753130-151787257 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 74.83 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    284 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336887
 protein coding gene Chr2:151753127-151787257 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026647
 protein coding gene Chr2:156419926-156454914 (+)
A/J MGP_AJ_G0026613
 protein coding gene Chr2:150188209-150222802 (+)
AKR/J MGP_AKRJ_G0026583
 protein coding gene Chr2:154571152-154606868 (+)
BALB/cJ MGP_BALBcJ_G0026622
 protein coding gene Chr2:150502630-150537420 (+)
C3H/HeJ MGP_C3HHeJ_G0026365
 protein coding gene Chr2:154957247-154992400 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027071
 protein coding gene Chr2:160979432-161015391 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024442
 protein coding gene Chr2:143803814-143836857 (+)
CAST/EiJ MGP_CASTEiJ_G0025826
 protein coding gene Chr2:155184812-155220105 (+)
CBA/J MGP_CBAJ_G0026343
 protein coding gene Chr2:166865663-166902041 (+)
DBA/2J MGP_DBA2J_G0026479
 protein coding gene Chr2:149412232-149447666 (+)
FVB/NJ MGP_FVBNJ_G0026444
 protein coding gene Chr2:147849224-147882543 (+)
LP/J MGP_LPJ_G0026583
 protein coding gene Chr2:156584186-156621165 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026466
 protein coding gene Chr2:171023045-171056927 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027126
 protein coding gene Chr2:154451864-154486100 (+)
PWK/PhJ MGP_PWKPhJ_G0025560
 protein coding gene Chr2:148935809-148969734 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025363
 protein coding gene Chr2:153289498-153322854 (+)
WSB/EiJ MGP_WSBEiJ_G0025896
 protein coding gene Chr2:155376320-155411669 (+)



Homology
more
  • Human Ortholog
    ANGPT4, angiopoietin 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANGPT4, angiopoietin 4
  • Synonyms
    ANG3, ANG4
  • Links
    NCBI Gene ID: 51378
    neXtProt AC: NX_Q9Y264
    UniProt: Q9Y264

  • Chr Location
    20p13; chr20:869900-916334 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    6
  • cDNA Data
    7
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027460 Ensembl Gene Model | MGI Sequence Detail 34128 C57BL/6J ±  kb
transcript ENSMUST00000028955 Ensembl | MGI Sequence Detail 2335 Not Applicable  
polypeptide ENSMUSP00000028955 Ensembl | MGI Sequence Detail 509 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000004025 angiopoietin-4
    (term hierarchy)
  • InterPro Domains
    IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
    IPR014716 Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
    IPR020837 Fibrinogen, conserved site
    IPR036056 Fibrinogen-like, C-terminal
Molecular
Reagents
less
  • All nucleic 8
    cDNA 7
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:329948 Kapiainen E, et al., Cooperation of Angiopoietin-2 and Angiopoietin-4 in Schlemm's Canal Maintenance. Invest Ophthalmol Vis Sci. 2022 Oct 3;63(11):1
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory