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Gng12 Gene Detail
Summary
  • Symbol
    Gng12
  • Name
    guanine nucleotide binding protein (G protein), gamma 12
  • Synonyms
    2010305F15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1336171
    NCBI Gene: 14701
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:66873381-66998334 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 30.68 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2919 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1336171
 protein coding gene Chr6:66873381-66998345 (+)
129S1/SvImJ ENSMUSG00200011386
 protein coding gene Chr6:63785949-63911743 (+)
A/J ENSMUSG00195041003
 protein coding gene Chr6:63530443-63656235 (+)
AKR/J ENSMUSG00220038902
 protein coding gene Chr6:63021251-63147484 (+)
BALB/cJ ENSMUSG00180032293
 protein coding gene Chr6:63886351-64012147 (+)
C3H/HeJ ENSMUSG00175036886
 protein coding gene Chr6:113439016-113564795 (-)
C57BL/6NJ ENSMUSG00215040525
 protein coding gene Chr6:63859337-63985134 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028470
 protein coding gene Chr6:61161346-61279586 (+)
CAST/EiJ ENSTCUG00005032800
 protein coding gene Chr6:64167377-64283678 (+)
CBA/J ENSMUSG00210038676
 protein coding gene Chr6:63676015-63801796 (+)
DBA/2J ENSMUSG00185042605
 protein coding gene Chr6:64247086-64372866 (+)
FVB/NJ ENSMUSG00205019941
 protein coding gene Chr6:63670706-63799820 (+)
JF1/MsJ ENSUMUG00000029225
 protein coding gene Chr6:63607385-63721121 (+)
LP/J ENSMUSG00230022562
 protein coding gene Chr6:65369638-65495423 (+)
NOD/ShiLtJ ENSMUSG00190026198
 protein coding gene Chr6:63549226-63662753 (+)
NZO/HlLtJ ENSMUSG00225018900
 protein coding gene Chr6:67362904-67476443 (+)
PWK/PhJ ENSLUMG00010020370
 protein coding gene Chr6:62818861-62936545 (+)
SPRET/EiJ ENSMSPG00010024644
 protein coding gene Chr6:64660809-64773546 (+)
WSB/EiJ ENSIUOG00005022849
 protein coding gene Chr6:64324363-64454877 (+)



Homology
more
  • Human Ortholog
    GNG12, G protein subunit gamma 12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNG12, G protein subunit gamma 12
  • Synonyms
    HG3A
  • Links
    NCBI Gene ID: 55970
    UniProt: Q9UBI6

  • Chr Location
    1p31.3; chr1:67701466-67833476 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    670
  • Tissues
    25
  • cDNA Data
    185
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036402 Ensembl Gene Model | MGI Sequence Detail 124954 C57BL/6J ±  kb
    transcript ENSMUST00000204511 Ensembl | MGI Sequence Detail 739 Not Applicable  
    polypeptide ENSMUSP00000145346 Ensembl | MGI Sequence Detail 83 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008105 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
      (term hierarchy)
    • InterPro Domains
      IPR036284 G-protein gamma-like domain superfamily
      IPR001770 G-protein, gamma subunit
      IPR015898 G-protein, gamma subunit-like domain
    Molecular
    Reagents
    less
    • All nucleic 185
      cDNA 185

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1889368, MGI:1889384, MGI:1889807, MGI:1919361, MGI:2141487
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:54663 Downes GB, et al., Chromosomal mapping of five mouse G protein gamma subunits. Genomics. 1999 Apr 1;57(1):173-6
    • Latest
      J:347348 Yim YY, et al., Specificities of Gbetagamma subunits for the SNARE complex before and after stimulation of alpha(2a)-adrenergic receptors. Sci Signal. 2021 Dec 21;14(714):eabc4970
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory