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Msc Gene Detail
Summary
  • Symbol
    Msc
  • Name
    musculin
  • Synonyms
    bHLHa22, MyoR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333884
    NCBI Gene: 17681
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:14823570-14826216 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 4.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333884
 protein coding gene Chr1:14823570-14826216 (-)
129S1/SvImJ ENSMUSG00200018430
 protein coding gene Chr1:12201521-12204171 (-)
A/J ENSMUSG00195026979
 protein coding gene Chr1:11989766-11992410 (-)
AKR/J ENSMUSG00220007993
 protein coding gene Chr1:12070104-12072750 (-)
BALB/cJ ENSMUSG00180022659
 protein coding gene Chr1:12056102-12058748 (-)
C3H/HeJ ENSMUSG00175000082
 protein coding gene Chr1:11989105-11991749 (-)
C57BL/6NJ ENSMUSG00215011680
 protein coding gene Chr1:12026256-12028900 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013959
 protein coding gene Chr1:10658567-10661204 (-)
CAST/EiJ ENSTCUG00005020827
 protein coding gene Chr1:12370882-12373527 (-)
CBA/J ENSMUSG00210002593
 protein coding gene Chr1:11855186-11857830 (-)
DBA/2J ENSMUSG00185003902
 protein coding gene Chr1:12918465-12921111 (-)
FVB/NJ ENSMUSG00205014314
 protein coding gene Chr1:12133115-12135761 (-)
JF1/MsJ ENSUMUG00000015242
 protein coding gene Chr1:12199454-12202256 (-)
LP/J ENSMUSG00230018779
 protein coding gene Chr1:12902901-12905551 (-)
NOD/ShiLtJ ENSMUSG00190027179
 protein coding gene Chr1:11963121-11965767 (-)
NZO/HlLtJ ENSMUSG00225004583
 protein coding gene Chr1:16289839-16292483 (-)
PWK/PhJ ENSLUMG00010020935
 protein coding gene Chr1:11817274-11819949 (-)
SPRET/EiJ ENSMSPG00010026873
 protein coding gene Chr1:12563408-12565572 (-)
WSB/EiJ ENSIUOG00005011180
 protein coding gene Chr1:11980005-11982649 (-)



Homology
more
  • Human Ortholog
    MSC, musculin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MSC, musculin
  • Synonyms
    ABF-1, ABF1, bHLHa22, MYOR
  • Links
    NCBI Gene ID: 9242
    UniProt: O60682

  • Chr Location
    8q13.3; chr8:71841552-71844496 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MSC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    12 phenotypes from multigenic genotypes
    8 phenotype references
Mice homozygous for a targeted mutation are obtained at predicted Mendelian ratios and exhibit no obvious phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    78
  • cDNA Data
    22
  • Literature Summary
    21
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17681 NCBI Gene Model | MGI Sequence Detail 2647 C57BL/6J ±  kb
transcript NM_001411712 RefSeq | MGI Sequence Detail 1891 ZRU/MplStud  
polypeptide O88940 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 2
    cDNA 24
    Primer pair 3
    Other 3

    Microarray probesets 4
References
more
  • Summaries
    All 57
    Developmental Gene Expression 21
    Gene Ontology 10
    Phenotypes 8
  • Earliest
    J:50698 Robb L, et al., musculin: a murine basic helix-loop-helix transcription factor gene expressed in embryonic skeletal muscle. Mech Dev. 1998 Aug;76(1-2):197-201
  • Latest
    J:348796 Jin L, et al., The muscle-enriched myokine Musclin impairs beige fat thermogenesis and systemic energy homeostasis via Tfr1/PKA signaling in male mice. Nat Commun. 2023 Jul 19;14(1):4257
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory