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Ppp1r17 Gene Detail
Summary
  • Symbol
    Ppp1r17
  • Name
    protein phosphatase 1, regulatory subunit 17
  • Synonyms
    Gsbs, G-substrate
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333876
    NCBI Gene: 19051
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:55994482-56009674 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.65 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333876
 protein coding gene Chr6:55994482-56009674 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030777
 protein coding gene Chr6:55462345-55479077 (+)
A/J MGP_AJ_G0030746
 protein coding gene Chr6:52874467-52889481 (+)
AKR/J MGP_AKRJ_G0030673
 protein coding gene Chr6:54665168-54682218 (+)
BALB/cJ MGP_BALBcJ_G0030758
 protein coding gene Chr6:53258620-53273994 (+)
C3H/HeJ MGP_C3HHeJ_G0030471
 protein coding gene Chr6:54697813-54712917 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031213
 protein coding gene Chr6:56693609-56710632 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028419
 protein coding gene Chr6:50482946-50498087 (+)
CAST/EiJ MGP_CASTEiJ_G0029874
 protein coding gene Chr6:54581246-54597703 (+)
CBA/J MGP_CBAJ_G0030445
 protein coding gene Chr6:59007439-59022474 (+)
DBA/2J MGP_DBA2J_G0030595
 protein coding gene Chr6:52774722-52790427 (+)
FVB/NJ MGP_FVBNJ_G0030547
 protein coding gene Chr6:52367229-52382559 (+)
LP/J MGP_LPJ_G0030680
 protein coding gene Chr6:55386834-55403370 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030581
 protein coding gene Chr6:61498222-61514744 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031243
 protein coding gene Chr6:54655290-54671032 (+)
PWK/PhJ MGP_PWKPhJ_G0029587
 protein coding gene Chr6:52451536-52467254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029421
 protein coding gene Chr6:54018960-54033983 (+)
WSB/EiJ MGP_WSBEiJ_G0029951
 protein coding gene Chr6:54687441-54705029 (+)



Homology
more
  • Human Ortholog
    PPP1R17, protein phosphatase 1 regulatory subunit 17
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP1R17, protein phosphatase 1 regulatory subunit 17
  • Synonyms
    C7orf16, GSBS
  • Links
    NCBI Gene ID: 10842
    neXtProt AC: NX_O96001
    UniProt: O96001

  • Chr Location
    7p14.3; chr7:31687215-31708455 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PPP1R17 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal retina.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    780
  • Tissues
    16
  • cDNA Data
    13
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19051 NCBI Gene Model | MGI Sequence Detail 15193 C57BL/6J ±  kb
    transcript NM_011153 RefSeq | MGI Sequence Detail 1757 ZRU/MplStud  
    polypeptide Q9Z2E4 UniProt | EBI | MGI Sequence Detail 159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 7
      Gene Ontology 3
      Phenotypes 6
    • Earliest
      J:38063 Sowden JC, et al., The identification of novel sequences expressed in the mouse notochord. Mamm Genome. 1997 Jan;8(1):42-4
    • Latest
      J:329049 Galdos FX, et al., devCellPy is a machine learning-enabled pipeline for automated annotation of complex multilayered single-cell transcriptomic data. Nat Commun. 2022 Sep 7;13(1):5271
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory