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Hsd17b10 Gene Detail
Summary
  • Symbol
    Hsd17b10
  • Name
    hydroxysteroid (17-beta) dehydrogenase 10
  • Synonyms
    Ads9, ERAB, Hadh2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333871
    NCBI Gene: 15108
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:150784892-150787438 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 68.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333871
 protein coding gene ChrX:150784841-150787438 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036180
 protein coding gene ChrX:149753661-149759670 (+)
A/J MGP_AJ_G0036156
 protein coding gene ChrX:148946712-148949319 (+)
AKR/J MGP_AKRJ_G0036082
 protein coding gene ChrX:153774946-153777513 (+)
BALB/cJ MGP_BALBcJ_G0036147
 protein coding gene ChrX:147135180-147141739 (+)
C3H/HeJ MGP_C3HHeJ_G0035855
 protein coding gene ChrX:149962255-149964814 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036672
 protein coding gene ChrX:154022748-154025833 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033496
 protein coding gene ChrX:140640113-140642704 (+)
CAST/EiJ MGP_CASTEiJ_G0035146
 protein coding gene ChrX:129379052-129382148 (+)
CBA/J MGP_CBAJ_G0035832
 protein coding gene ChrX:158548983-158551595 (+)
DBA/2J MGP_DBA2J_G0035990
 protein coding gene ChrX:148020846-148023413 (+)
FVB/NJ MGP_FVBNJ_G0035924
 protein coding gene ChrX:147148896-147151910 (+)
LP/J MGP_LPJ_G0036081
 protein coding gene ChrX:150850954-150853509 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035960
 protein coding gene ChrX:166709408-166714983 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036707
 protein coding gene ChrX:149270873-149274392 (+)
PWK/PhJ MGP_PWKPhJ_G0034840
 protein coding gene ChrX:126331071-126333650 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034666
 protein coding gene ChrX:129840763-129843316 (+)
WSB/EiJ MGP_WSBEiJ_G0035281
 protein coding gene ChrX:147334505-147338074 (+)



Homology
more
  • Human Ortholog
    HSD17B10, hydroxysteroid 17-beta dehydrogenase 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSD17B10, hydroxysteroid 17-beta dehydrogenase 10
  • Synonyms
    17b-HSD10, ABAD, CAMR, DUPXp11.22, ERAB, HADH2, HCD2, HSD10MD, MHBD, MRPP2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1
  • Links
    NCBI Gene ID: 3028
    neXtProt AC: NX_Q99714
    UniProt: Q99714

  • Chr Location
    Xp11.22; chrX:53431258-53434376 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HSD17B10 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    143
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 15108 NCBI Gene Model | MGI Sequence Detail 2547 C57BL/6J ±  kb
transcript NM_016763 RefSeq | MGI Sequence Detail 938 C57BL/6  
polypeptide O08756 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 143
    cDNA 143

    Microarray probesets 6
References
more
  • Summaries
    All 42
    Developmental Gene Expression 2
    Gene Ontology 12
    Phenotypes 2
  • Earliest
    J:51470 Hansis C, et al., The gene for the Alzheimer-associated beta-amyloid-binding protein (ERAB) is differentially expressed in the testicular Leydig cells of the azoospermic by w/w(v) mouse. Eur J Biochem. 1998 Nov 15;258(1):53-60
  • Latest
    J:213151 Bogenhagen DF, et al., Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids. Cell Metab. 2014 Apr 1;19(4):618-29
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory