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Ate1 Gene Detail
Summary
  • Symbol
    Ate1
  • Name
    arginyltransferase 1
  • Synonyms
    Ate1_1, Ate1_2, Ate1_3, Ate1_4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333870
    NCBI Gene: 11907
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:129993223-130122099 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 73.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    563 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333870
protein coding gene Chr7:129993219-130122349 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033091
protein coding gene Chr7:134910669-135042659 (-)
A/J MGP_AJ_G0033073
protein coding gene Chr7:131239833-131366218 (-)
AKR/J MGP_AKRJ_G0033005
protein coding gene Chr7:134721246-134848823 (-)
BALB/cJ MGP_BALBcJ_G0033074
protein coding gene Chr7:130912179-131040880 (-)
C3H/HeJ MGP_C3HHeJ_G0032788
protein coding gene Chr7:134592116-134720225 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033584
protein coding gene Chr7:140108939-140252249 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030556
protein coding gene Chr7:132397300-132520532 (-)
CAST/EiJ MGP_CASTEiJ_G0032118
protein coding gene Chr7:126397166-126531410 (-)
CBA/J MGP_CBAJ_G0032761
protein coding gene Chr7:144905734-145039858 (-)
DBA/2J MGP_DBA2J_G0032913
protein coding gene Chr7:129243151-129369668 (-)
FVB/NJ MGP_FVBNJ_G0032866
protein coding gene Chr7:129094054-129219148 (-)
LP/J MGP_LPJ_G0033007
protein coding gene Chr7:136392676-136522488 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032898
protein coding gene Chr7:145868625-146000663 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033603
protein coding gene Chr7:133653698-133783877 (-)
PWK/PhJ MGP_PWKPhJ_G0031824
protein coding gene Chr7:122305652-122431730 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031670
protein coding gene Chr7:120480867-120609209 (-)
WSB/EiJ MGP_WSBEiJ_G0032229
protein coding gene Chr7:134657377-134788314 (-)



Homology
more
  • Human Ortholog
    ATE1, arginyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATE1, arginyltransferase 1
  • Links
    NCBI Gene ID: 11101
    neXtProt AC: NX_O95260
    UniProt: O95260

  • Chr Location
    10q26.13; chr10:121709393-121928801 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    61 phenotypes from 5 alleles in 7 genetic backgrounds
    6 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in developmental defects of the heart and embryonic lethality between E13.5 and E15.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030850 Ensembl Gene Model | MGI Sequence Detail 128877 C57BL/6J ±  kb
    transcript ENSMUST00000216011 Ensembl | MGI Sequence Detail 1680 Not Applicable  
    polypeptide ENSMUSP00000148888 Ensembl | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      cDNA 104
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:2141882, MGI:2142257
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 24
    • Earliest
      J:51609 Kwon YT, et al., Alternative splicing results in differential expression, activity, and localization of the two forms of arginyl-tRNA-protein transferase, a component of the N-end rule pathway. Mol Cell Biol. 1999 Jan;19(1):182-93
    • Latest
      J:344833 Shim SM, et al., The Cys-N-degron pathway modulates pexophagy through the N-terminal oxidation and arginylation of ACAD10. Autophagy. 2023 Jun;19(6):1642-1661

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory