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Klf9 Gene Detail
Summary
  • Symbol
    Klf9
  • Name
    Kruppel-like transcription factor 9
  • Synonyms
    2310051E17Rik, Bteb1, BTEB-1, Klf9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333856
    NCBI Gene: 16601
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:23118590-23145493 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 17.90 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    731 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333856
 protein coding gene Chr19:23118590-23145498 (+)
129S1/SvImJ ENSMUSG00200020329
 protein coding gene Chr19:19848282-19875185 (+)
A/J ENSMUSG00195017293
 protein coding gene Chr19:19982398-20009436 (+)
AKR/J ENSMUSG00220010129
 protein coding gene Chr19:19999884-20026899 (+)
BALB/cJ ENSMUSG00180012956
 protein coding gene Chr19:20329087-20355977 (+)
C3H/HeJ ENSMUSG00175003324
 protein coding gene Chr19:19691404-19717948 (+)
C57BL/6NJ ENSMUSG00215014976
 protein coding gene Chr19:19728458-19755376 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022820
 protein coding gene Chr19:20292188-20319033 (+)
CAST/EiJ ENSTCUG00005008492
 protein coding gene Chr19:19585108-19612011 (+)
CBA/J ENSMUSG00210012842
 protein coding gene Chr19:19922785-19949326 (+)
DBA/2J ENSMUSG00185025521
 protein coding gene Chr19:20309038-20335583 (+)
FVB/NJ ENSMUSG00205003651
 protein coding gene Chr19:19757143-19784038 (+)
JF1/MsJ ENSUMUG00000037009
 protein coding gene Chr19:20535664-20562219 (+)
LP/J ENSMUSG00230025349
 protein coding gene Chr19:21158201-21185103 (+)
NOD/ShiLtJ ENSMUSG00190020228
 protein coding gene Chr19:19683829-19710707 (+)
NZO/HlLtJ ENSMUSG00225033521
 protein coding gene Chr19:24900314-24928881 (+)
PWK/PhJ ENSLUMG00010008289
 protein coding gene Chr19:19865233-19891762 (+)
SPRET/EiJ ENSMSPG00010017089
 protein coding gene Chr19:19847254-19872601 (+)
WSB/EiJ ENSIUOG00005007064
 protein coding gene Chr19:19402986-19429871 (+)



Homology
more
  • Human Ortholog
    KLF9, KLF transcription factor 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF9, KLF transcription factor 9
  • Synonyms
    BTEB, BTEB1
  • Links
    NCBI Gene ID: 687
    UniProt: Q13886

  • Chr Location
    9q21.12; chr9:70384604-70414657 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display only mild neurological defects evident by impaired performance in rotarod and contextual fear-conditioning tests.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    983
  • Tissues
    160
  • cDNA Data
    17
  • Literature Summary
    20
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16601 NCBI Gene Model | MGI Sequence Detail 26904 C57BL/6J ±  kb
transcript NM_010638 RefSeq | MGI Sequence Detail 4481 C57BL/6  
polypeptide O35739 UniProt | EBI | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 18
    Primer pair 7
    Other 2

    Microarray probesets 10
Other
Accession IDs
less
MGI:1917523, MGI:2147456
References
more
  • Summaries
    All 116
    Developmental Gene Expression 20
    Gene Ontology 8
    Phenotypes 49
  • Earliest
    J:41831 Fujii H, et al., Metabolic inactivation of retinoic acid by a novel P450 differentially expressed in developing mouse embryos. EMBO J. 1997 Jul 16;16(14):4163-73
  • Latest
    J:361627 Edmondson E, et al., TRalpha1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility. Sci Rep. 2025 Jan 31;15(1):3892
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory