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Magea4 Gene Detail
Summary
  • Symbol
    Magea4
  • Name
    MAGE family member A4
  • Synonyms
    Mage-a4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333839
    NCBI Gene: 17140
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:71265623-71266570 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333839
protein coding gene ChrX:71264599-71266611 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035790
protein coding gene ChrX:67887274-67888221 (+)
A/J MGP_AJ_G0035774
protein coding gene ChrX:68130024-68130971 (+)
AKR/J MGP_AKRJ_G0035696
protein coding gene ChrX:69963536-69964483 (+)
BALB/cJ MGP_BALBcJ_G0035761
protein coding gene ChrX:67155968-67156915 (+)
C3H/HeJ MGP_C3HHeJ_G0035464
protein coding gene ChrX:68406102-68407049 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036291
protein coding gene ChrX:69963578-69964525 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033138
protein coding gene ChrX:67326065-67327177 (+)
CAST/EiJ MGP_CASTEiJ_G0034756
protein coding gene ChrX:53778396-53779752 (+)
CBA/J MGP_CBAJ_G0035439
protein coding gene ChrX:71893411-71894358 (+)
DBA/2J MGP_DBA2J_G0035592
protein coding gene ChrX:67593060-67594007 (+)
FVB/NJ MGP_FVBNJ_G0035543
protein coding gene ChrX:66952118-66953065 (+)
LP/J MGP_LPJ_G0035681
protein coding gene ChrX:68736499-68737446 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035578
protein coding gene ChrX:74470177-74471124 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036312
protein coding gene ChrX:67751554-67752501 (+)
PWK/PhJ MGP_PWKPhJ_G0034456
protein coding gene ChrX:51787762-51788709 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034291
protein coding gene ChrX:54681538-54682485 (+)
WSB/EiJ MGP_WSBEiJ_G0034898
protein coding gene ChrX:67072662-67073609 (+)



Homology
more
  • Human Ortholog
    MAGEA10, MAGE family member A10
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAGEA10, MAGE family member A10
  • Synonyms
    CT1.10, MAGE10
  • Links
    NCBI Gene ID: 4109
    neXtProt AC: NX_P43363
    UniProt: P43363

  • Chr Location
    Xq28; chrX:152133310-152138578 (-)  GRCh38

  • Human Ortholog
    MAGEA11, MAGE family member A11
  • Synonyms
    CT1.11, MAGE11, MAGE-11, MAGEA-11
  • Links
    NCBI Gene ID: 4110
    neXtProt AC: NX_P43364
    UniProt: P43364

  • Chr Location
    Xq28; chrX:149688193-149717268 (+)  GRCh38

  • Human Ortholog
    MAGEA12, MAGE family member A12
  • Synonyms
    CT1.12, MAGE12
  • Links
    NCBI Gene ID: 4111
    neXtProt AC: NX_P43365
    UniProt: P43365

  • Chr Location
    Xq28; chrX:152733757-152737669 (+)  GRCh38

  • Human Ortholog
    MAGEA2, MAGE family member A2
  • Synonyms
    CT1.2, MAGE2, MAGEA2A
  • Links
    NCBI Gene ID: 4101
    neXtProt AC: NX_P43356
    UniProt: P43356

  • Chr Location
    Xq28

  • Human Ortholog
    MAGEA2B, MAGE family member A2B
  • Synonyms
    CT1.2, MAGE2
  • Links
    NCBI Gene ID: 266740
    neXtProt AC: NX_P43356
    UniProt: P43356

  • Chr Location
    Xq28; chrX:152714586-152718607 (+)  GRCh38

  • Human Ortholog
    MAGEA4, MAGE family member A4
  • Synonyms
    CT1.4, MAGE4, MAGE-41, MAGE4A, MAGE4B, MAGE-X2
  • Links
    NCBI Gene ID: 4103
    neXtProt AC: NX_P43358
    UniProt: P43358

  • Chr Location
    Xq28; chrX:151912474-151925171 (+)  GRCh38

  • Human Ortholog
    MAGEA8, MAGE family member A8
  • Synonyms
    CT1.8, MAGE8
  • Links
    NCBI Gene ID: 4107
    neXtProt AC: NX_P43361
    UniProt: P43361

  • Chr Location
    Xq28; chrX:149881141-149885835 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033343 Ensembl Gene Model | MGI Sequence Detail 948 C57BL/6J ±  kb
transcript ENSMUST00000048675 Ensembl | MGI Sequence Detail 948 Not Applicable  
polypeptide ENSMUSP00000046715 Ensembl | MGI Sequence Detail 315 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR002190 MAGE homology domain
    IPR041898 MAGE homology domain, winged helix WH1 motif
    IPR041899 MAGE homology domain, winged helix WH2 motif
    IPR037445 Melanoma-associated antigen
    IPR021072 Melanoma associated antigen, N-terminal
Molecular
Reagents
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  • All nucleic 6
    cDNA 4
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 31
    Developmental Gene Expression 10
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:52871 De Plaen E, et al., A new family of mouse genes homologous to the human MAGE genes. Genomics. 1999 Jan 15;55(2):176-84
  • Latest
    J:342299 Fon Tacer K, et al., MAGE cancer-testis antigens protect the mammalian germline under environmental stress. Sci Adv. 2019 May;5(5):eaav4832

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory