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Slc22a3 Gene Detail
Summary
  • Symbol
    Slc22a3
  • Name
    solute carrier family 22 (organic cation transporter), member 3
  • Synonyms
    EMT, Oct3, Orct3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333817
    NCBI Gene: 20519
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:12638859-12726591 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 8.52 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    291 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333817
 protein coding gene Chr17:12637847-12726591 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023146
 protein coding gene Chr17:10073040-10166286 (-)
A/J MGP_AJ_G0023114
 protein coding gene Chr17:9913434-10001349 (-)
AKR/J MGP_AKRJ_G0023078
 protein coding gene Chr17:9740376-9828447 (-)
BALB/cJ MGP_BALBcJ_G0023114
 protein coding gene Chr17:9686961-9774213 (-)
C3H/HeJ MGP_C3HHeJ_G0022877
 protein coding gene Chr17:9987054-10073790 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023557
 protein coding gene Chr17:10461868-10552843 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021051
 protein coding gene Chr17:4446163-4534055 (+)
CAST/EiJ MGP_CASTEiJ_G0022391
 protein coding gene Chr17:10041139-10143353 (-)
CBA/J MGP_CBAJ_G0022849
 protein coding gene Chr17:10834939-10934740 (-)
DBA/2J MGP_DBA2J_G0022982
 protein coding gene Chr17:9537687-9626696 (-)
FVB/NJ MGP_FVBNJ_G0022952
 protein coding gene Chr17:9487304-9576727 (-)
LP/J MGP_LPJ_G0023054
 protein coding gene Chr17:9884200-9976434 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022971
 protein coding gene Chr17:10459112-10549982 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023583
 protein coding gene Chr17:10000690-10088493 (-)
PWK/PhJ MGP_PWKPhJ_G0022139
 protein coding gene Chr17:9239707-9333674 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021969
 protein coding gene Chr17:9414096-9506045 (-)
WSB/EiJ MGP_WSBEiJ_G0022448
 protein coding gene Chr17:10328236-10418837 (-)



Homology
more
  • Human Ortholog
    SLC22A3, solute carrier family 22 member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC22A3, solute carrier family 22 member 3
  • Synonyms
    EMT, EMTH, OCT3
  • Links
    NCBI Gene ID: 6581
    neXtProt AC: NX_O75751
    UniProt: O75751

  • Chr Location
    6q25.3; chr6:160348378-160452577 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to paraquat-induced dopamine neuron neurotoxicity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    838
  • Tissues
    33
  • cDNA Data
    11
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20519 NCBI Gene Model | MGI Sequence Detail 87733 C57BL/6J ±  kb
    transcript NM_011395 RefSeq | MGI Sequence Detail 3501 ZRU/MplStud  
    polypeptide Q9WTW5 UniProt | EBI | MGI Sequence Detail 551 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 6
      cDNA 12
      Primer pair 7
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 14
      Gene Ontology 19
      Phenotypes 17
    • Earliest
      J:52875 Verhaagh S, et al., Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. Genomics. 1999 Jan 15;55(2):209-18
    • Latest
      J:337209 Sardar D, et al., Induction of astrocytic Slc22a3 regulates sensory processing through histone serotonylation. Science. 2023 Jun 16;380(6650):eade0027
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory