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Hs3st4 Gene Detail
Summary
  • Symbol
    Hs3st4
  • Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 4
  • Synonyms
    Gm6915
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333792
    NCBI Gene: 628779
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:123582092-123998212 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 67.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11540 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333792
 protein coding gene Chr7:123581586-123998212 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032965
 protein coding gene Chr7:128151988-128592724 (+)
A/J MGP_AJ_G0032948
 protein coding gene Chr7:124801867-125225125 (+)
AKR/J MGP_AKRJ_G0032880
 protein coding gene Chr7:127976705-128412755 (+)
BALB/cJ MGP_BALBcJ_G0032953
 protein coding gene Chr7:124463677-124886745 (+)
C3H/HeJ MGP_C3HHeJ_G0032663
 protein coding gene Chr7:127885469-128319259 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033459
 protein coding gene Chr7:133152955-133597866 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030431
 protein coding gene Chr7:126068114-126474536 (+)
CAST/EiJ MGP_CASTEiJ_G0031991
 protein coding gene Chr7:119678778-120114970 (+)
CBA/J MGP_CBAJ_G0032636
 protein coding gene Chr7:137630423-138099813 (+)
DBA/2J MGP_DBA2J_G0032788
 protein coding gene Chr7:122791735-123208785 (+)
FVB/NJ MGP_FVBNJ_G0032741
 protein coding gene Chr7:122632832-123051641 (+)
LP/J MGP_LPJ_G0032882
 protein coding gene Chr7:129584872-130029517 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032773
 protein coding gene Chr7:138946015-139386194 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033479
 protein coding gene Chr7:126969653-127404071 (+)
PWK/PhJ MGP_PWKPhJ_G0031699
 protein coding gene Chr7:115751352-116178254 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031545
 protein coding gene Chr7:113789660-114233519 (+)
WSB/EiJ MGP_WSBEiJ_G0032104
 protein coding gene Chr7:127898614-128346716 (+)



Homology
more
  • Human Ortholog
    HS3ST4, heparan sulfate-glucosamine 3-sulfotransferase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HS3ST4, heparan sulfate-glucosamine 3-sulfotransferase 4
  • Synonyms
    30ST4, 3-OST-4, 3OST4, h3-OST-4
  • Links
    NCBI Gene ID: 9951
    UniProt: Q9Y661

  • Chr Location
    16p12.1; chr16:25691959-26137685 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    942
  • Tissues
    133
  • cDNA Data
    5
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000078591 Ensembl Gene Model | MGI Sequence Detail 416121 C57BL/6J ±  kb
transcript ENSMUST00000106437 Ensembl | MGI Sequence Detail 3189 Not Applicable  
polypeptide ENSMUSP00000102045 Ensembl | MGI Sequence Detail 449 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
    2.8.2.-
  • InterPro Domains
    IPR037359 Heparan sulfate sulfotransferase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000863 Sulfotransferase domain
  • GlyGen
    D3YVV6 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 9
    cDNA 5
    Primer pair 3
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGI:3645059
References
more
  • Summaries
    All 29
    Developmental Gene Expression 9
    Gene Ontology 5
    Phenotypes 1
  • Earliest
    J:53037 Shworak NW, et al., Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. J Biol Chem. 1999 Feb 19;274(8):5170-84
  • Latest
    J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory