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Pld3 Gene Detail
Summary
  • Symbol
    Pld3
  • Name
    phospholipase D family member 3
  • Synonyms
    Sam-9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333782
    NCBI Gene: 18807
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:27231425-27252643 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 15.92 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333782
 protein coding gene Chr7:27231090-27252643 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031916
 protein coding gene Chr7:26195286-26217452 (-)
A/J MGP_AJ_G0031895
 protein coding gene Chr7:25560412-25582038 (-)
AKR/J MGP_AKRJ_G0031825
 protein coding gene Chr7:26242631-26263841 (-)
BALB/cJ MGP_BALBcJ_G0031900
 protein coding gene Chr7:25775357-25796798 (-)
C3H/HeJ MGP_C3HHeJ_G0031622
 protein coding gene Chr7:26620075-26644148 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032365
 protein coding gene Chr7:27059058-27083616 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029417
 protein coding gene Chr7:26786062-26807279 (-)
CAST/EiJ MGP_CASTEiJ_G0030957
 protein coding gene Chr7:19925648-19948557 (-)
CBA/J MGP_CBAJ_G0031587
 protein coding gene Chr7:28253052-28283588 (-)
DBA/2J MGP_DBA2J_G0031739
 protein coding gene Chr7:25355619-25376951 (-)
FVB/NJ MGP_FVBNJ_G0031695
 protein coding gene Chr7:25458897-25479599 (-)
LP/J MGP_LPJ_G0031819
 protein coding gene Chr7:26525386-26547180 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031730
 protein coding gene Chr7:27822823-27847634 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032396
 protein coding gene Chr7:25781691-25806264 (-)
PWK/PhJ MGP_PWKPhJ_G0030681
 protein coding gene Chr7:20391971-20413137 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030515
 protein coding gene Chr7:16764358-16787269 (-)
WSB/EiJ MGP_WSBEiJ_G0031065
 protein coding gene Chr7:26064755-26088702 (-)



Homology
more
  • Human Ortholog
    PLD3, phospholipase D family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLD3, phospholipase D family member 3
  • Synonyms
    AD19, HUK4, HU-K4, SCA46
  • Links
    NCBI Gene ID: 23646
    neXtProt AC: NX_Q8IV08
    UniProt: Q8IV08

  • Chr Location
    19q13.2; chr19:40348456-40389472 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PLD3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout alters the response of macrophages to single-stranded oligodeoxynucleic acids (ODNs). The enzyme digests unphosphorylated 5' ends of single-stranded ODNs without secondary structure in endolysosomes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    836
  • Tissues
    107
  • cDNA Data
    175
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003363 Ensembl Gene Model | MGI Sequence Detail 21219 C57BL/6J ±  kb
transcript ENSMUST00000117095 Ensembl | MGI Sequence Detail 2282 Not Applicable  
polypeptide ENSMUSP00000113820 Ensembl | MGI Sequence Detail 488 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 180
    Genomic 1
    cDNA 176
    Primer pair 1
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 49
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 14
  • Earliest
    J:51052 Roy IL, et al., Quantitative trait loci implicated in corpus callosum midsagittal area in mice. Brain Res. 1998 Nov 16;811(1-2):173-6
  • Latest
    J:340267 Yuan P, et al., PLD3 affects axonal spheroids and network defects in Alzheimer's disease. Nature. 2022 Dec;612(7939):328-337
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory