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Hdac6 Gene Detail
Summary
  • Symbol
    Hdac6
  • Name
    histone deacetylase 6
  • Synonyms
    mHDA2, Sfc6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1333752
    NCBI Gene: 15185
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7796359-7814128 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.58 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1333752
 protein coding gene ChrX:7796355-7814284 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035535
 protein coding gene ChrX:2556586-2576039 (-)
A/J MGP_AJ_G0035512
 protein coding gene ChrX:2514370-2533277 (-)
AKR/J MGP_AKRJ_G0035445
 protein coding gene ChrX:2634925-2654674 (-)
BALB/cJ MGP_BALBcJ_G0035509
 protein coding gene ChrX:2542523-2560204 (-)
C3H/HeJ MGP_C3HHeJ_G0035217
 protein coding gene ChrX:2605595-2623962 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036033
 protein coding gene ChrX:2644266-2662254 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032908
 protein coding gene ChrX:2075960-2093704 (-)
CAST/EiJ MGP_CASTEiJ_G0034518
 protein coding gene ChrX:2495620-2516910 (-)
CBA/J MGP_CBAJ_G0035187
 protein coding gene ChrX:2769249-2789347 (-)
DBA/2J MGP_DBA2J_G0035344
 protein coding gene ChrX:2537639-2555428 (-)
FVB/NJ MGP_FVBNJ_G0035291
 protein coding gene ChrX:2499322-2516965 (-)
LP/J MGP_LPJ_G0035421
 protein coding gene ChrX:2579840-2597606 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035331
 protein coding gene ChrX:2733019-2751638 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036051
 protein coding gene ChrX:2542649-2562396 (-)
PWK/PhJ MGP_PWKPhJ_G0034218
 protein coding gene ChrX:2468643-2486527 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034057
 protein coding gene ChrX:2519849-2538599 (-)
WSB/EiJ MGP_WSBEiJ_G0034641
 protein coding gene ChrX:2550674-2569511 (-)



Homology
more
  • Human Ortholog
    HDAC6, histone deacetylase 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HDAC6, histone deacetylase 6
  • Synonyms
    CPBHM, HD6, JM21, KDAC6, PPP1R90
  • Links
    NCBI Gene ID: 10013
    neXtProt AC: NX_Q9UBN7
    UniProt: Q9UBN7

  • Chr Location
    Xp11.23; chrX:48801377-48824982 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HDAC6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 4 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    60 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Although mice homozygous for a knock-out allele exhibit global tubulin hyperacetylation, they are viable and fertile and display only a moderately impaired immune response and a minor increase in cancellous bone mineral density.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    176
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    889
  • Tissues
    58
  • cDNA Data
    133
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031161 Ensembl Gene Model | MGI Sequence Detail 17770 C57BL/6J ±  kb
    transcript ENSMUST00000115642 Ensembl | MGI Sequence Detail 4069 Not Applicable  
    polypeptide ENSMUSP00000111306 Ensembl | MGI Sequence Detail 1149 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      Genomic 2
      cDNA 133
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1343096
    References
    more
    • Summaries
      All 185
      Developmental Gene Expression 22
      Gene Ontology 33
      Phenotypes 60
    • Earliest
      J:52197 Verdel A, et al., Identification of a new family of higher eukaryotic histone deacetylases. Coordinate expression of differentiation-dependent chromatin modifiers. J Biol Chem. 1999 Jan 22;274(4):2440-5
    • Latest
      J:345971 Ranjbarvaziri S, et al., Targeting HDAC6 to treat heart failure with preserved ejection fraction in mice. Nat Commun. 2024 Feb 26;15(1):1352
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory