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Lin7b Gene Detail
Summary
  • Symbol
    Lin7b
  • Name
    lin-7 homolog B, crumbs cell polarity complex component
  • Synonyms
    LIN-7B, MALS-2, Veli2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330858
    NCBI Gene: 22342
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45017315-45019988 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.28 cM, cytoband B2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330858
 protein coding gene Chr7:45017315-45020007 (-)
129S1/SvImJ ENSMUSG00200022428
 protein coding gene Chr7:32613898-32616590 (-)
A/J ENSMUSG00195047488
 protein coding gene Chr7:36644859-36647551 (-)
AKR/J ENSMUSG00220008071
 protein coding gene Chr7:30946499-30949191 (-)
BALB/cJ ENSMUSG00180029056
 protein coding gene Chr7:33520287-33522980 (-)
C3H/HeJ ENSMUSG00175036577
 protein coding gene Chr7:34049821-34052513 (-)
C57BL/6NJ ENSMUSG00215040338
 protein coding gene Chr7:33310224-33312916 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029713
 protein coding gene Chr7:47305431-47308119 (-)
CAST/EiJ ENSTCUG00005042993
 protein coding gene Chr7:37033007-37035696 (-)
CBA/J ENSMUSG00210046337
 protein coding gene Chr7:34421376-34424068 (-)
DBA/2J ENSMUSG00185044582
 protein coding gene Chr7:38296634-38299326 (-)
FVB/NJ ENSMUSG00205046071
 protein coding gene Chr7:33965757-33968449 (-)
JF1/MsJ ENSUMUG00000037509
 protein coding gene Chr7:42780379-42783069 (-)
LP/J ENSMUSG00230050495
 protein coding gene Chr7:43723098-43725791 (-)
NOD/ShiLtJ ENSMUSG00190045520
 protein coding gene Chr7:34293464-34296156 (-)
NZO/HlLtJ ENSMUSG00225017538
 protein coding gene Chr7:41933971-41936666 (-)
PWK/PhJ ENSLUMG00010047317
 protein coding gene Chr7:33258135-33260825 (-)
SPRET/EiJ ENSMSPG00010029168
 protein coding gene Chr7:33024934-33027628 (-)
WSB/EiJ ENSIUOG00005020910
 protein coding gene Chr7:34838100-34840794 (-)



Homology
more
  • Human Ortholog
    LIN7B, lin-7 cell polarity scaffold B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIN7B, lin-7 cell polarity scaffold B
  • Synonyms
    LIN-7B, MALS-2, MALS2, VELI2
  • Links
    NCBI Gene ID: 64130
    UniProt: Q9HAP6

  • Chr Location
    19q13.33; chr19:49114324-49118460 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotypes from multigenic genotypes
    5 phenotype references
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    11
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22342 NCBI Gene Model | MGI Sequence Detail 2674 C57BL/6J ±  kb
transcript NM_011698 RefSeq | MGI Sequence Detail 762 C57BL/6  
polypeptide O88951 UniProt | EBI | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 6
References
more
  • Summaries
    All 39
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 5
  • Earliest
    J:49850 Butz S, et al., A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Cell. 1998 Sep 18;94(6):773-82
  • Latest
    J:212850 Karataeva AR, et al., C-terminal interactors of the AMPA receptor auxiliary subunit Shisa9. PLoS One. 2014;9(2):e87360
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory