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Rasal1 Gene Detail
Summary
  • Symbol
    Rasal1
  • Name
    RAS protein activator like 1 (GAP1 like)
  • Synonyms
    MRASAL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330842
    NCBI Gene: 19415
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:120786877-120817662 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 60.63 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330842
 protein coding gene Chr5:120786105-120817662 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030011
 protein coding gene Chr5:124047025-124080295 (+)
A/J MGP_AJ_G0029975
 protein coding gene Chr5:118895551-118926127 (+)
AKR/J MGP_AKRJ_G0029914
 protein coding gene Chr5:122735179-122766237 (+)
BALB/cJ MGP_BALBcJ_G0029986
 protein coding gene Chr5:120312052-120344354 (+)
C3H/HeJ MGP_C3HHeJ_G0029706
 protein coding gene Chr5:123269877-123306571 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030441
 protein coding gene Chr5:128690113-128720874 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027667
 protein coding gene Chr5:113603350-113634442 (+)
CAST/EiJ MGP_CASTEiJ_G0029115
 protein coding gene Chr5:122398520-122433884 (+)
CBA/J MGP_CBAJ_G0029674
 protein coding gene Chr5:133681476-133724103 (+)
DBA/2J MGP_DBA2J_G0029824
 protein coding gene Chr5:118980902-119011511 (+)
FVB/NJ MGP_FVBNJ_G0029780
 protein coding gene Chr5:117909771-117942646 (+)
LP/J MGP_LPJ_G0029912
 protein coding gene Chr5:124494526-124527646 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029811
 protein coding gene Chr5:137647835-137682037 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030482
 protein coding gene Chr5:122316096-122347216 (+)
PWK/PhJ MGP_PWKPhJ_G0028828
 protein coding gene Chr5:117741963-117774336 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028667
 protein coding gene Chr5:119974446-120006984 (+)
WSB/EiJ MGP_WSBEiJ_G0029190
 protein coding gene Chr5:122904005-122937136 (+)



Homology
more
  • Human Ortholog
    RASAL1, RAS protein activator like 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASAL1, RAS protein activator like 1
  • Synonyms
    RASAL
  • Links
    NCBI Gene ID: 8437
    neXtProt AC: NX_O95294
    UniProt: O95294

  • Chr Location
    12q24.13; chr12:113098819-113136756 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit increased kidney fibrosis upon challenge with unilateral ureteral obstruction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    1
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029602 Ensembl Gene Model | MGI Sequence Detail 30786 C57BL/6J ±  kb
    transcript ENSMUST00000031606 Ensembl | MGI Sequence Detail 3212 Not Applicable  
    polypeptide ENSMUSP00000031606 Ensembl | MGI Sequence Detail 799 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 7
      cDNA 22

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:331889 Xu R, et al., A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers. Sci Transl Med. 2022 Jul 20;14(654):eabf1922
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory