About   Help   FAQ
Dmrt2 Gene Detail
Summary
  • Symbol
    Dmrt2
  • Name
    doublesex and mab-3 related transcription factor 2
  • Synonyms
    Terra
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330307
    NCBI Gene: 226049
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:25649775-25656355 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 20.53 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330307
 protein coding gene Chr19:25649758-25656355 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025004
 protein coding gene Chr19:23985881-23992400 (+)
A/J MGP_AJ_G0024981
 protein coding gene Chr19:22681937-22688525 (+)
AKR/J MGP_AKRJ_G0024949
 protein coding gene Chr19:23547950-23554866 (+)
BALB/cJ MGP_BALBcJ_G0024980
 protein coding gene Chr19:22728733-22735296 (+)
C3H/HeJ MGP_C3HHeJ_G0024736
 protein coding gene Chr19:23539678-23547618 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025421
 protein coding gene Chr19:24721494-24728092 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022840
 protein coding gene Chr19:22807209-22813700 (+)
CAST/EiJ MGP_CASTEiJ_G0024206
 protein coding gene Chr19:23280300-23286807 (+)
CBA/J MGP_CBAJ_G0024714
 protein coding gene Chr19:25788472-25794992 (+)
DBA/2J MGP_DBA2J_G0024846
 protein coding gene Chr19:22675331-22681847 (+)
FVB/NJ MGP_FVBNJ_G0024808
 protein coding gene Chr19:22577777-22584348 (+)
LP/J MGP_LPJ_G0024931
 protein coding gene Chr19:23941340-23947608 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024835
 protein coding gene Chr19:25767813-25775665 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025476
 protein coding gene Chr19:23564599-23571108 (+)
PWK/PhJ MGP_PWKPhJ_G0023954
 protein coding gene Chr19:22320338-22326208 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023758
 protein coding gene Chr19:22838922-22845398 (+)
WSB/EiJ MGP_WSBEiJ_G0024273
 protein coding gene Chr19:23591605-23598143 (+)



Homology
more
  • Human Ortholog
    DMRT2, doublesex and mab-3 related transcription factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMRT2, doublesex and mab-3 related transcription factor 2
  • Synonyms
    DSXL-2
  • Links
    NCBI Gene ID: 10655
    neXtProt AC: NX_Q9Y5R5
    UniProt: Q9Y5R5

  • Chr Location
    9p24.3; chr9:1049858-1057552 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display perinatal lethality due to breathing difficulties, multiple axial skeletal defects including kinked tails and rib and vertebral malformations, and abnormal somite organization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    895
  • Tissues
    94
  • cDNA Data
    21
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048138 Ensembl Gene Model | MGI Sequence Detail 6581 C57BL/6J ±  kb
    transcript ENSMUST00000053068 Ensembl | MGI Sequence Detail 2337 Not Applicable  
    polypeptide ENSMUSP00000059654 Ensembl | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 22
      Primer pair 7
      Other 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 23
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:52603 Meng A, et al., A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. Development. 1999 Mar;126(6):1259-68
    • Latest
      J:327901 Ye Q, et al., Understanding the development of oral epithelial organs through single cell transcriptomic analysis. Development. 2022 Aug 15;149(16):dev200539
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory