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Ovol1 Gene Detail
Summary
  • Symbol
    Ovol1
  • Name
    ovo like zinc finger 1
  • Synonyms
    movo1, Ovo1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330290
    NCBI Gene: 18426
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:5599165-5610603 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.34 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    65 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330290
 protein coding gene Chr19:5599164-5610674 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024715
 protein coding gene Chr19:2522605-2534043 (-)
A/J MGP_AJ_G0024681
 protein coding gene Chr19:2384685-2396123 (-)
AKR/J MGP_AKRJ_G0024654
 protein coding gene Chr19:2447392-2458830 (-)
BALB/cJ MGP_BALBcJ_G0024681
 protein coding gene Chr19:2380967-2392405 (-)
C3H/HeJ MGP_C3HHeJ_G0024449
 protein coding gene Chr19:2463548-2474986 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025128
 protein coding gene Chr19:2578223-2589661 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022558
 protein coding gene Chr19:2285995-2297544 (-)
CAST/EiJ MGP_CASTEiJ_G0023921
 protein coding gene Chr19:2485305-2496778 (-)
CBA/J MGP_CBAJ_G0024421
 protein coding gene Chr19:2703201-2714655 (-)
DBA/2J MGP_DBA2J_G0024548
 protein coding gene Chr19:2381704-2393158 (-)
FVB/NJ MGP_FVBNJ_G0024514
 protein coding gene Chr19:2371309-2382747 (-)
LP/J MGP_LPJ_G0024634
 protein coding gene Chr19:2505290-2516728 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024544
 protein coding gene Chr19:2546793-2558231 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025176
 protein coding gene Chr19:2468803-2480241 (-)
PWK/PhJ MGP_PWKPhJ_G0023667
 protein coding gene Chr19:2403913-2415420 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023472
 protein coding gene Chr19:2450467-2465139 (-)
WSB/EiJ MGP_WSBEiJ_G0023983
 protein coding gene Chr19:2477540-2488997 (-)



Homology
more
  • Human Ortholog
    OVOL1, ovo like transcriptional repressor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OVOL1, ovo like transcriptional repressor 1
  • Synonyms
    HOVO1
  • Links
    NCBI Gene ID: 5017
    neXtProt AC: NX_O14753
    UniProt: O14753

  • Chr Location
    11q13.1; chr11:65787063-65797214 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mutant homozygotes show reduced growth, abnormal hair, and cystic kidneys. Females are subfertile with dilated uterus and cervix, and constricted or imperforate vagina. Mutant males have small testes, with few mature germ cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    850
  • Tissues
    70
  • cDNA Data
    26
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18426 NCBI Gene Model | MGI Sequence Detail 11439 C57BL/6J ±  kb
    transcript NM_019935 RefSeq | MGI Sequence Detail 2900 C57BL/6  
    polypeptide Q9WTJ2 UniProt | EBI | MGI Sequence Detail 267 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 1
      cDNA 26
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147769
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 18
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:23315 Farese RV Jr, et al., Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1774-8
    • Latest
      J:341642 Schwartz B, et al., ZNF750 Regulates Skin Barrier Function by Driving Cornified Envelope and Lipid Processing Pathways. J Invest Dermatol. 2023 Sep 3;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory