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Aanat Gene Detail
Summary
  • Symbol
    Aanat
  • Name
    arylalkylamine N-acetyltransferase
  • Synonyms
    Nat-2, Nat4, SNAT
Location &
Maps
more
  • Sequence Map
    Chr11:116482547-116489022 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.43 cM, cytoband E2
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1328365
 protein coding gene Chr11:116477258-116489022 (+)
129S1/SvImJ ENSMUSG00200050464
 protein coding gene Chr11:113844921-113848916 (+)
A/J ENSMUSG00195027236
 protein coding gene Chr11:113552808-113556822 (+)
AKR/J ENSMUSG00220024833
 protein coding gene Chr11:113655273-113659292 (+)
BALB/cJ ENSMUSG00180051311
 protein coding gene Chr11:113846080-113850083 (+)
C3H/HeJ ENSMUSG00175035270
 protein coding gene Chr11:113804553-113808569 (+)
C57BL/6NJ ENSMUSG00215042401
 protein coding gene Chr11:113344716-113348709 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017448
 protein coding gene Chr11:112450676-112462383 (+)
CAST/EiJ ENSTCUG00005031287
 protein coding gene Chr11:113204957-113208946 (+)
CBA/J ENSMUSG00210048947
 protein coding gene Chr11:113524543-113528557 (+)
DBA/2J ENSMUSG00185022345
 protein coding gene Chr11:113837531-113841534 (+)
FVB/NJ ENSMUSG00205043539
 protein coding gene Chr11:113651192-113655201 (+)
JF1/MsJ ENSUMUG00000053042
 protein coding gene Chr11:114106823-114110898 (+)
LP/J ENSMUSG00230049922
 protein coding gene Chr11:114897810-114901824 (+)
NOD/ShiLtJ ENSMUSG00190031988
 protein coding gene Chr11:113868516-113872511 (+)
NZO/HlLtJ ENSMUSG00225052434
 protein coding gene Chr11:116946865-116950858 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010040049
 protein coding gene Chr11:114148490-114152558 (+)
WSB/EiJ ENSIUOG00005039584
 protein coding gene Chr11:113609831-113613832 (+)



Homology
more
  • Human Ortholog
    AANAT, aralkylamine N-acetyltransferase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AANAT, aralkylamine N-acetyltransferase
  • Synonyms
    DSPS, SNAT
  • Links
    NCBI Gene ID: 15
    UniProt: Q16613

  • Chr Location
    17q25.1; chr17:76452749-76470122 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human AANAT associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in abnormal melatonin production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    55
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    698
  • Tissues
    99
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11298 NCBI Gene Model | MGI Sequence Detail 6476 C57BL/6J ±  kb
    transcript NR_033223 RefSeq | MGI Sequence Detail 1472 ZRU/MplStud  
    polypeptide O88816 UniProt | EBI | MGI Sequence Detail 205 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 3
      cDNA 8
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12779, MGD-MRK-12781, MGI:97280
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 2
      Gene Ontology 13
      Phenotypes 44
    • Earliest
      J:8150 Ebihara S, et al., Genetic control of melatonin synthesis in the pineal gland of the mouse. Science. 1986 Jan 31;231(4737):491-3
    • Latest
      J:386376 Faraci G, et al., The TREM2 R47H variant is associated with liver-plasma-brain axis dyshomeostasis in the 5xFAD mouse model of Alzheimer's disease. Neurobiol Aging. 2026 Apr 29;165:24-37
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory