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Lcp2 Gene Detail
Summary
  • Symbol
    Lcp2
  • Name
    lymphocyte cytosolic protein 2
  • Synonyms
    m1Khoe, SLP-76, SLP76, twm
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321402
    NCBI Gene: 16822
  • Alliance
    genome feature page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:33996928-34042281 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 19.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1333 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321402
 protein coding gene Chr11:33996920-34042295 (+)
129S1/SvImJ ENSMUSG00200008964
 protein coding gene Chr11:31036146-31081528 (+)
A/J ENSMUSG00195007007
 protein coding gene Chr11:30944567-30989935 (+)
AKR/J ENSMUSG00220003176
 protein coding gene Chr11:31141370-31186788 (+)
BALB/cJ ENSMUSG00180001752
 protein coding gene Chr11:30977490-31022923 (+)
C3H/HeJ ENSMUSG00175003616
 protein coding gene Chr11:30950602-30995974 (+)
C57BL/6NJ ENSMUSG00215007987
 protein coding gene Chr11:30907938-30953326 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016200
 protein coding gene Chr11:29640320-29685350 (+)
CAST/EiJ ENSTCUG00005028537
 protein coding gene Chr11:30833318-30878838 (+)
CBA/J ENSMUSG00210009382
 protein coding gene Chr11:30842452-30887876 (+)
DBA/2J ENSMUSG00185018676
 protein coding gene Chr11:31029730-31075103 (+)
FVB/NJ ENSMUSG00205011394
 protein coding gene Chr11:31031509-31076984 (+)
JF1/MsJ ENSUMUG00000004381
 protein coding gene Chr11:31286938-31331512 (+)
LP/J ENSMUSG00230003784
 protein coding gene Chr11:32195228-32240630 (+)
NOD/ShiLtJ ENSMUSG00190007125
 protein coding gene Chr11:31116635-31161192 (+)
NZO/HlLtJ ENSMUSG00225030199
 protein coding gene Chr11:34085995-34131349 (+)
PWK/PhJ ENSLUMG00010016852
 protein coding gene Chr11:30947301-30991847 (+)
SPRET/EiJ ENSMSPG00010002215
 protein coding gene Chr11:31330485-31374674 (+)
WSB/EiJ ENSIUOG00005002013
 protein coding gene Chr11:31026349-31071721 (+)



Homology
more
  • Human Ortholog
    LCP2, lymphocyte cytosolic protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LCP2, lymphocyte cytosolic protein 2
  • Synonyms
    IMD81, SLP-76, SLP76
  • Links
    NCBI Gene ID: 3937
    UniProt: Q13094

  • Chr Location
    5q35.1; chr5:170246233-170297820 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LCP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 8 alleles in 9 genetic backgrounds
    29 phenotypes from multigenic genotypes
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
T cell development is blocked and T cell receptor signaling impaired in homozygous point mutants. Double positive thymocyte and single positive T cell numbers are much reduced. Both positive and negative thymocyte selection is abnormal. Mice have high IgG and IgE levels and exhibit autoimmunity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    602
  • Tissues
    1
  • cDNA Data
    35
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16822 NCBI Gene Model | MGI Sequence Detail 45354 C57BL/6J ±  kb
    transcript NM_010696 RefSeq | MGI Sequence Detail 3622 C57BL/6  
    polypeptide Q60787 UniProt | EBI | MGI Sequence Detail 533 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 38

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144122, MGI:2144608, MGI:3584401, MGI:5491499
    References
    more
    • Summaries
      All 134
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 84
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/08/2026
    MGI 6.24     		The Jackson Laboratory