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Gdf2 Gene Detail
Summary
  • Symbol
    Gdf2
  • Name
    growth differentiation factor 2
  • Synonyms
    Bmp9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1321394
    NCBI Gene: 12165
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:33662996-33669155 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.80 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    306 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1321394
 protein coding gene Chr14:33662996-33669155 (+)
129S1/SvImJ ENSMUSG00200037764
 protein coding gene Chr14:25521877-25528070 (+)
A/J ENSMUSG00195013097
 protein coding gene Chr14:26563706-26569869 (+)
AKR/J ENSMUSG00220033818
 protein coding gene Chr14:25682412-25688577 (+)
BALB/cJ ENSMUSG00180028798
 protein coding gene Chr14:25652159-25658320 (+)
C3H/HeJ ENSMUSG00175036916
 protein coding gene Chr14:25719320-25725481 (+)
C57BL/6NJ ENSMUSG00215031231
 protein coding gene Chr14:25956040-25962201 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019106
 protein coding gene Chr14:26256906-26263134 (+)
CAST/EiJ ENSTCUG00005021190
 protein coding gene Chr14:25799634-25805795 (+)
CBA/J ENSMUSG00210042350
 protein coding gene Chr14:25966515-25972674 (+)
DBA/2J ENSMUSG00185037668
 protein coding gene Chr14:30236284-30242439 (+)
FVB/NJ ENSMUSG00205016245
 protein coding gene Chr14:25824025-25830180 (+)
JF1/MsJ ENSUMUG00000045257
 protein coding gene Chr14:37512141-37518336 (+)
LP/J ENSMUSG00230036830
 protein coding gene Chr14:37549264-37555459 (+)
NOD/ShiLtJ ENSMUSG00190018720
 protein coding gene Chr14:25976519-25982612 (+)
NZO/HlLtJ ENSMUSG00225041731
 protein coding gene Chr14:31850897-31857056 (+)
PWK/PhJ ENSLUMG00010020086
 protein coding gene Chr14:14095949-14102146 (+)
SPRET/EiJ ENSMSPG00010042034
 protein coding gene Chr14:27661044-27667374 (+)
WSB/EiJ ENSIUOG00005011301
 protein coding gene Chr14:25808594-25814687 (+)



Homology
more
  • Human Ortholog
    GDF2, growth differentiation factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDF2, growth differentiation factor 2
  • Synonyms
    BMP-9, BMP9, HHT5
  • Links
    NCBI Gene ID: 2658
    UniProt: Q9UK05

  • Chr Location
    10q11.22; chr10:47322454-47327588 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GDF2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    15 phenotypes from multigenic genotypes
    3 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show arteriovenous malformations, skeletal anomalies, and abnormal retinal vasculature after anti-BMP10-antibody treatment. Homozygotes for a different null allele show abnormal retinal and tracheal vasculature and tracheal lymphatic vessels after anti-BMP10 treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    80
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    23
  • cDNA Data
    10
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12165 NCBI Gene Model | MGI Sequence Detail 6160 C57BL/6J ±  kb
    transcript NM_019506 RefSeq | MGI Sequence Detail 2988 C57BL/6  
    polypeptide Q9WV56 UniProt | EBI | MGI Sequence Detail 428 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 10
      Primer pair 4
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 14
      Gene Ontology 13
      Phenotypes 24
    • Earliest
      J:48647 Celeste AJ, et al., Bone morphogenetic protein-9, a new member of the TGF-beta superfamily. J Bone Miner Res. 1994;Suppl:S136 (Abstr. 64)
    • Latest
      J:375941 Chen L, et al., Hepatic-derived BMP9 is involved in hepatic fibrosis-induced kidney injury through inhibition of renal VEGFA. Biochem Pharmacol. 2024 Jun 15;226:116371
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory