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Hipk1 Gene Detail
Summary
  • Symbol
    Hipk1
  • Name
    homeodomain interacting protein kinase 1
  • Synonyms
    1110062K04Rik, Myak
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314873
    NCBI Gene: 15257
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:103647131-103698879 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.52 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314873
 protein coding gene Chr3:103647131-103699210 (-)
129S1/SvImJ ENSMUSG00200043793
 protein coding gene Chr3:100255352-100306871 (-)
A/J ENSMUSG00195045827
 protein coding gene Chr3:100668981-100720394 (-)
AKR/J ENSMUSG00220035718
 protein coding gene Chr3:99028839-99080348 (-)
BALB/cJ ENSMUSG00180035354
 protein coding gene Chr3:100597068-100648509 (-)
C3H/HeJ ENSMUSG00175023042
 protein coding gene Chr3:100151333-100202734 (-)
C57BL/6NJ ENSMUSG00215016432
 protein coding gene Chr3:100917031-100968780 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025453
 protein coding gene Chr3:97809513-97861343 (-)
CAST/EiJ ENSTCUG00005019555
 protein coding gene Chr3:100870829-100922543 (-)
CBA/J ENSMUSG00210050696
 protein coding gene Chr3:100773335-100824745 (-)
DBA/2J ENSMUSG00185019889
 protein coding gene Chr3:101253198-101304948 (-)
FVB/NJ ENSMUSG00205021712
 protein coding gene Chr3:99833910-99885420 (-)
JF1/MsJ ENSUMUG00000035086
 protein coding gene Chr3:99994119-100046113 (-)
LP/J ENSMUSG00230015015
 protein coding gene Chr3:103183691-103235207 (-)
NOD/ShiLtJ ENSMUSG00190042801
 protein coding gene Chr3:101449083-101500529 (-)
NZO/HlLtJ ENSMUSG00225017712
 protein coding gene Chr3:105650827-105702264 (-)
PWK/PhJ ENSLUMG00010025788
 protein coding gene Chr3:100059259-100110421 (-)
SPRET/EiJ ENSMSPG00010039098
 protein coding gene Chr3:100281038-100331809 (-)
WSB/EiJ ENSIUOG00005030498
 protein coding gene Chr3:100788096-100840024 (-)



Homology
more
  • Human Ortholog
    HIPK1, homeodomain interacting protein kinase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIPK1, homeodomain interacting protein kinase 1
  • Synonyms
    Myak, Nbak2
  • Links
    NCBI Gene ID: 204851
    UniProt: Q86Z02

  • Chr Location
    1p13.2; chr1:113929324-113977869 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile, do not develop spontaneous tumors, and are resistant to DMBA-induced skin tumor formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    620
  • Tissues
    16
  • cDNA Data
    157
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008730 Ensembl Gene Model | MGI Sequence Detail 51749 C57BL/6J ±  kb
    transcript ENSMUST00000118317 Ensembl | MGI Sequence Detail 7939 Not Applicable  
    polypeptide ENSMUSP00000113998 Ensembl | MGI Sequence Detail 1210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      16 Sequences
    • Protein Ontology
      PR:000008566 homeodomain-interacting protein kinase 1
      (term hierarchy)
    • EC
      2.7.11.1
    • InterPro Domains
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050494 Serine/threonine and dual-specificity kinase
      IPR008271 Serine/threonine-protein kinase, active site
    • GlyGen
      O88904 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 161
      cDNA 158
      Primer pair 3
      Antibodies 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916099
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 16
      Phenotypes 17
    • Earliest
      J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory