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Usp9y Gene Detail
Summary
  • Symbol
    Usp9y
  • Name
    ubiquitin specific peptidase 9, Y chromosome
  • Synonyms
    Dffry, Fafl2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313274
    NCBI Gene: 107868
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrY:1298961-1459782 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome Y, cytoband p
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    138 from dbSNP Build 142
  • Strain Annotations
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313274
 protein coding gene ChrY:1298961-1459782 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    USP9Y, ubiquitin specific peptidase 9 Y-linked
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP9Y, ubiquitin specific peptidase 9 Y-linked
  • Synonyms
    DFFRY, FAF-Y, SPGFY2
  • Links
    NCBI Gene ID: 8287
    neXtProt AC: NX_O00507
    UniProt: O00507

  • Chr Location
    Yq11.221; chrY:12537650-12860839 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human USP9Y associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    20
  • cDNA Data
    1
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 107868 NCBI Gene Model | MGI Sequence Detail 160822 C57BL/6J ±  kb
transcript NM_148943 RefSeq | MGI Sequence Detail 8094 Not Specified  
polypeptide F8VPU6 UniProt | EBI | MGI Sequence Detail 2556 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    3.4.19.12
  • InterPro Domains
    IPR016024 Armadillo-type fold
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR021905 Ubiquitin C-terminal hydrolase-like, DUF3517
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
Molecular
Reagents
less
  • All nucleic 7
    Genomic 3
    cDNA 1
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 28
    Developmental Gene Expression 6
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:45388 Brown GM, et al., Characterisation of the coding sequence and fine mapping of the human DFFRY gene and comparative expression analysis and mapping to the Sxrb interval of the mouse Y chromosome of the Dffry gene. Hum Mol Genet. 1998 Jan;7(1):97-107
  • Latest
    J:246359 Kuroki S, et al., Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance. PLoS Genet. 2017 Sep;13(9):e1007034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory