About   Help   FAQ
Alcam Gene Detail
Summary
  • Symbol
    Alcam
  • Name
    activated leukocyte cell adhesion molecule
  • Synonyms
    BEN, CD166, DM-GRASP, MGC:27910, MuSC, SC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313266
    NCBI Gene: 11658
  • Alliance
  • Transcription Start Sites
    68 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:52069359-52273444 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 32.88 cM, cytoband B5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5857 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313266
protein coding gene Chr16:52069359-52274437 (-)
129S1/SvImJ ENSMUSG00200021256
protein coding gene Chr16:48944623-49145571 (-)
A/J ENSMUSG00195003392
protein coding gene Chr16:48557090-48758056 (-)
AKR/J ENSMUSG00220022325
protein coding gene Chr16:48918541-49119511 (-)
BALB/cJ ENSMUSG00180027845
protein coding gene Chr16:48761607-48962575 (-)
C3H/HeJ ENSMUSG00175025025
protein coding gene Chr16:49064376-49265086 (-)
C57BL/6NJ ENSMUSG00215007703
protein coding gene Chr16:48878667-49079630 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020805
protein coding gene Chr16:48928877-49130546 (-)
CAST/EiJ ENSTCUG00005012551
protein coding gene Chr16:49147401-49341749 (-)
CBA/J ENSMUSG00210016734
protein coding gene Chr16:49062791-49261746 (-)
DBA/2J ENSMUSG00185010038
protein coding gene Chr16:48941735-49142695 (-)
FVB/NJ ENSMUSG00205011737
protein coding gene Chr16:48828836-49032881 (-)
JF1/MsJ ENSUMUG00000026843
protein coding gene Chr16:49164367-49367887 (-)
LP/J ENSMUSG00230027143
protein coding gene Chr16:51488806-51693393 (-)
NOD/ShiLtJ ENSMUSG00190018021
protein coding gene Chr16:48976689-49177632 (-)
NZO/HlLtJ ENSMUSG00225025408
protein coding gene Chr16:54601695-54802644 (-)
PWK/PhJ ENSLUMG00010027502
protein coding gene Chr16:48973357-49167495 (-)
SPRET/EiJ ENSMSPG00010007001
protein coding gene Chr16:49337272-49530984 (-)
WSB/EiJ ENSIUOG00005013231
protein coding gene Chr16:49111751-49312537 (-)



Homology
more
  • Human Ortholog
    ALCAM, activated leukocyte cell adhesion molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ALCAM, activated leukocyte cell adhesion molecule
  • Synonyms
    CD166, MEMD
  • Links
    NCBI Gene ID: 214
    UniProt: Q13740

  • Chr Location
    3q13.11; chr3:105366706-105576909 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal motor neuron and retinal ganglion cell morphology and retinal dysplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11658 NCBI Gene Model | MGI Sequence Detail 204086 C57BL/6J ±  kb
    transcript NM_009655 RefSeq | MGI Sequence Detail 5063 C57BL/6  
    polypeptide Q61490 UniProt | EBI | MGI Sequence Detail 583 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 16
      Primer pair 6
      Other 4
      Antibodies 10

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2146511
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 68
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:19352 Kanki JP, et al., The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse. J Neurobiol. 1994 Jul;25(7):831-45
    • Latest
      J:375094 Murillo-Rincon AP, et al., Positional programs in early murine facial development and their role in human facial shape variability. Nat Commun. 2025 Nov 18;16(1):10112

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory