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Plp2 Gene Detail
Summary
  • Symbol
    Plp2
  • Name
    proteolipid protein 2
  • Synonyms
    mIMA4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298382
    NCBI Gene: 18824
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:7534180-7537629 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 3.45 cM, cytoband A2-A3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    107 from dbSNP Build 142
  • Strain Annotations
    15
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298382
 protein coding gene ChrX:7534180-7537629 (-)
129S1/SvImJ ENSMUSG00200032076
 protein coding gene ChrX:2234803-2238252 (-)
A/J ENSMUSG00195037535
 protein coding gene ChrX:2257753-2261203 (-)
AKR/J ENSMUSG00220033090
 protein coding gene ChrX:2240376-2243826 (-)
BALB/cJ ENSMUSG00180026179
 protein coding gene ChrX:2234394-2237844 (-)
C3H/HeJ ENSMUSG00175031955
 protein coding gene ChrX:2269451-2272900 (-)
C57BL/6NJ ENSMUSG00215038141
 protein coding gene ChrX:2933290-2936740 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032890
 protein coding gene ChrX:1808702-1812195 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210033646
 protein coding gene ChrX:2286318-2289767 (-)
DBA/2J ENSMUSG00185027556
 protein coding gene ChrX:8903456-8906905 (-)
FVB/NJ ENSMUSG00205024730
 protein coding gene ChrX:2280081-2283530 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230026859
 protein coding gene ChrX:13423690-13427139 (-)
NOD/ShiLtJ ENSMUSG00190035674
 protein coding gene ChrX:2255252-2258702 (-)
NZO/HlLtJ ENSMUSG00225045504
 protein coding gene ChrX:18689189-18692638 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005031073
 protein coding gene ChrX:16263726-16267175 (+)



Homology
more
  • Human Ortholog
    PLP2, proteolipid protein 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLP2, proteolipid protein 2
  • Synonyms
    A4, A4LSB
  • Links
    NCBI Gene ID: 5355
    UniProt: Q04941

  • Chr Location
    Xp11.23; chrX:49171787-49175235 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males hemizygous for a null allele show increased neuronal apoptosis to ER stress and hypoxia in vitro and in a neonatal hypoxia-ischemia model in vivo. Mutant mouse embryonic fibroblasts show delayed ER trafficking, increased basal ER stress and increased sensitivity to ER stress-induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    674
  • Tissues
    34
  • cDNA Data
    17
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18824 NCBI Gene Model | MGI Sequence Detail 3450 C57BL/6J ±  kb
transcript NM_019755 RefSeq | MGI Sequence Detail 1178 ZRU/MplStud  
polypeptide Q9R1Q7 UniProt | EBI | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 22
    Genomic 5
    cDNA 17

    Microarray probesets 6
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:49742 Kuroiwa A, et al., Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Cytogenet Cell Genet. 1998;81(3-4):208-12
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory