Mcm6 MGI Mouse Gene Detail - MGI:1298227 - minichromosome maintenance complex component 6

Symbol

Mcm6
Name

minichromosome maintenance complex component 6
Synonyms

D1Wsu22e, Mcmd6

Feature Type

protein coding gene
IDs

MGI:1298227
NCBI Gene: 17219
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:128259327-128287401 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 55.80 cM, cytoband E4
Mapping Data

4 experiments

SNPs within 2kb

1021 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1298227	protein coding gene	Chr1:128259312-128287442 (-)
129S1/SvImJ	ENSMUSG00200008561	protein coding gene	Chr1:125812488-125840756 (-)
A/J	ENSMUSG00195038869	protein coding gene	Chr1:124898124-124926203 (-)
AKR/J	ENSMUSG00220047929	protein coding gene	Chr1:124748911-124777179 (-)
BALB/cJ	ENSMUSG00180035793	protein coding gene	Chr1:125466713-125494981 (-)
C3H/HeJ	ENSMUSG00175042871	protein coding gene	Chr1:125166768-125194845 (-)
C57BL/6NJ	ENSMUSG00215042974	protein coding gene	Chr1:125180874-125208954 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014546	protein coding gene	Chr1:120022633-120050741 (-)
CAST/EiJ	ENSTCUG00005030647	protein coding gene	Chr1:124101939-124129818 (-)
CBA/J	ENSMUSG00210025909	protein coding gene	Chr1:125047040-125075113 (-)
DBA/2J	ENSMUSG00185001983	protein coding gene	Chr1:129410863-129439135 (-)
FVB/NJ	ENSMUSG00205027637	protein coding gene	Chr1:124371139-124399410 (-)
JF1/MsJ	ENSUMUG00000000993	protein coding gene	Chr1:128538555-128567165 (-)
LP/J	ENSMUSG00230000971	protein coding gene	Chr1:128990830-129019098 (-)
NOD/ShiLtJ	ENSMUSG00190032957	protein coding gene	Chr1:125050190-125078263 (-)
NZO/HlLtJ	ENSMUSG00225004732	protein coding gene	Chr1:132727547-132755622 (-)
PWK/PhJ	ENSLUMG00010024076	protein coding gene	Chr1:124171325-124199639 (-)
SPRET/EiJ	ENSMSPG00010039740	protein coding gene	Chr1:126941001-126969004 (-)
WSB/EiJ	ENSIUOG00005041141	protein coding gene	Chr1:124770573-124798631 (-)

Human Ortholog

MCM6, minichromosome maintenance complex component 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MCM6, minichromosome maintenance complex component 6
Synonyms

MCG40308, Mis5, P105MCM
Links

HGNC:6949

NCBI Gene ID: 4175

UniProt: Q14566
Chr Location

2q21.3; chr2:135839626-135876479 (-) GRCh38

MGI Vertebrate Homology

Mcm6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MCM6
Gene Tree

Mcm6

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotypes from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

11
Radiation induced

1
Genomic Mutations

3 involving Mcm6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

39 strains or lines available

Mice homozygous for a gene trapped allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit increased micronulei-containing red blood cells.

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All GO Annotations

58
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

665
Tissues

43
cDNA Data

228
Literature Summary

15

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mcm6, mcm6.2

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All Sequences

89
RefSeq

4
UniProt

6
CCDS

CCDS15252.1, CCDS83586.1

Ensembl

ENSMUSG00000026355 (Evidence)
NCBI Gene

17219

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026355	Ensembl Gene Model \| MGI Sequence Detail	28075	C57BL/6J	± kb
transcript	ENSMUST00000027601	Ensembl \| MGI Sequence Detail	2910	Not Applicable
polypeptide	ENSMUSP00000027601	Ensembl \| MGI Sequence Detail	821	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010248 DNA replication licensing factor MCM6

(term hierarchy)
EC

3.6.4.12
InterPro Domains

IPR008049 DNA replication licensing factor Mcm6

IPR041024 Mcm6, C-terminal winged-helix domain

IPR041562 MCM, AAA-lid domain

IPR001208 MCM domain

IPR027925 MCM, N-terminal domain

IPR033762 MCM OB domain

IPR018525 Mini-chromosome maintenance, conserved site

IPR031327 Mini-chromosome maintenance protein

IPR012340 Nucleic acid-binding, OB-fold

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

P97311 1 site, 1 O-linked glycan (1 site)

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All nucleic 234

Genomic 2

cDNA 229

Primer pair 3

Antibodies 3

Microarray probesets 5

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MGD-MRK-34267, MGI:106573

Summaries

All 87

Developmental Gene Expression 15

Gene Ontology 17

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:388028 Rueda EM, et al., Electron transport chain activity balances cell cycle progression and differentiation of retinal progenitor cells. Exp Eye Res. 2026 Jun 17;:111127

TSS for Mcm6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13451	Chr1:128287347-128287435 (-)	10 bp
Tssr13450	Chr1:128287334-128287346 (-)	61 bp
Tssr13449	Chr1:128271204-128271217 (-)	16,190 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24