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F2rl2 Gene Detail
Summary
  • Symbol
    F2rl2
  • Name
    coagulation factor II thrombin receptor like 2
  • Synonyms
    PAR-3, PAR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298208
    NCBI Gene: 14064
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:95833428-95839276 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 50.38 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    357 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298208
 protein coding gene Chr13:95833361-95839276 (+)
129S1/SvImJ ENSMUSG00200008532
 protein coding gene Chr13:90335811-90341468 (+)
A/J ENSMUSG00195027551
 protein coding gene Chr13:90835367-90841025 (+)
AKR/J ENSMUSG00220013402
 protein coding gene Chr13:89288748-89294603 (+)
BALB/cJ ENSMUSG00180031985
 protein coding gene Chr13:91369449-91375304 (+)
C3H/HeJ ENSMUSG00175015299
 protein coding gene Chr13:91532917-91538772 (+)
C57BL/6NJ ENSMUSG00215027011
 protein coding gene Chr13:91434480-91440366 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018801
 protein coding gene Chr13:89363679-89369549 (+)
CAST/EiJ ENSTCUG00005009103
 protein coding gene Chr13:90634357-90640018 (+)
CBA/J ENSMUSG00210010700
 protein coding gene Chr13:90854873-90860728 (+)
DBA/2J ENSMUSG00185018242
 protein coding gene Chr13:94515576-94521431 (+)
FVB/NJ ENSMUSG00205008056
 protein coding gene Chr13:90316784-90322639 (+)
JF1/MsJ ENSUMUG00000021738
 protein coding gene Chr13:94226054-94231940 (+)
LP/J ENSMUSG00230033452
 protein coding gene Chr13:104533012-104538898 (+)
NOD/ShiLtJ ENSMUSG00190028059
 protein coding gene Chr13:91215293-91221179 (+)
NZO/HlLtJ ENSMUSG00225032655
 protein coding gene Chr13:97046905-97052760 (+)
PWK/PhJ ENSLUMG00010011047
 protein coding gene Chr13:90319949-90325839 (+)
SPRET/EiJ ENSMSPG00010008175
 protein coding gene Chr13:91583779-91588557 (+)
WSB/EiJ ENSIUOG00005029346
 protein coding gene Chr13:90238477-90244332 (+)



Homology
more
  • Human Ortholog
    F2RL2, coagulation factor II thrombin receptor like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F2RL2, coagulation factor II thrombin receptor like 2
  • Synonyms
    PAR-3, PAR3
  • Links
    NCBI Gene ID: 2151
    UniProt: O00254

  • Chr Location
    5q13.3; chr5:76615482-76623413 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in prolonged bleeding times, delayed and reduced thrombin responses in platelets, and protection against thrombosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    125
  • cDNA Data
    12
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14064 NCBI Gene Model | MGI Sequence Detail 5849 C57BL/6J ±  kb
transcript NM_010170 RefSeq | MGI Sequence Detail 2464 Not Specified  
polypeptide O08675 UniProt | EBI | MGI Sequence Detail 369 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 3
    cDNA 13
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 66
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 24
  • Earliest
    J:49190 Ishihara H, et al., Protease-activated receptor 3 is a second thrombin receptor in humans. Nature. 1997 Apr 3;386(6624):502-6
  • Latest
    J:385469 Cao D, et al., Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling. Am J Pathol. 2022 Feb;192(2):361-378
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory