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Ppp2r2d Gene Detail
Summary
  • Symbol
    Ppp2r2d
  • Name
    protein phosphatase 2, regulatory subunit B, delta
  • Synonyms
    1300017E19Rik, D7Ertd753e, MDS026, mKIAA1541
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289252
    NCBI Gene: 52432
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:138448073-138484786 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 82.95 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1005 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289252
 protein coding gene Chr7:138447808-138484786 (+)
129S1/SvImJ ENSMUSG00200044292
 protein coding gene Chr7:125030701-125040881 (+)
129S1/SvImJ ENSMUSGG00200054468
 protein coding gene Chr7:125004213-125006490 (+)
A/J ENSMUSG00195032774
 protein coding gene Chr7:129501433-129511613 (+)
A/J ENSMUSGG00195055000
 protein coding gene Chr7:129474943-129477218 (+)
AKR/J ENSMUSGG00220054422
 protein coding gene Chr7:122963703-122965982 (+)
AKR/J ENSMUSG00220024617
 protein coding gene Chr7:122990198-123000378 (+)
BALB/cJ ENSMUSGG00180055077
 protein coding gene Chr7:126178716-126180993 (+)
BALB/cJ ENSMUSG00180036713
 protein coding gene Chr7:126205206-126215386 (+)
C3H/HeJ ENSMUSGG00175054710
 protein coding gene Chr7:126907008-126909285 (+)
C3H/HeJ ENSMUSG00175038145
 protein coding gene Chr7:126933497-126943678 (+)
C57BL/6NJ ENSMUSG00215043589
 protein coding gene Chr7:126206978-126217159 (+)
C57BL/6NJ ENSMUSGG00215055292
 protein coding gene Chr7:126180487-126182768 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030610
 protein coding gene Chr7:140946096-140984095 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055029
 protein coding gene Chr7:126655303-126657584 (+)
CBA/J ENSMUSG00210026063
 protein coding gene Chr7:126681796-126691976 (+)
DBA/2J ENSMUSGG00185057447
 protein coding gene Chr7:130943833-130946104 (+)
DBA/2J ENSMUSG00185014185
 protein coding gene Chr7:130970312-130980491 (+)
FVB/NJ ENSMUSGG00205054122
 protein coding gene Chr7:126630130-126632409 (+)
FVB/NJ ENSMUSG00205040958
 protein coding gene Chr7:126656621-126666805 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230040184
 protein coding gene Chr7:137133747-137143927 (+)
LP/J ENSMUSGG00230055834
 protein coding gene Chr7:137107263-137109538 (+)
NOD/ShiLtJ ENSMUSGG00190054610
 protein coding gene Chr7:126779270-126781541 (+)
NOD/ShiLtJ ENSMUSG00190024355
 protein coding gene Chr7:126805745-126815924 (+)
NZO/HlLtJ ENSMUSGG00225055690
 protein coding gene Chr7:135326260-135328610 (+)
NZO/HlLtJ ENSMUSG00225050370
 protein coding gene Chr7:135353052-135363257 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PPP2R2D, protein phosphatase 2 regulatory subunit Bdelta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R2D, protein phosphatase 2 regulatory subunit Bdelta
  • Synonyms
    B55D, B55delta, MDS026
  • Links
    NCBI Gene ID: 55844
    UniProt: Q66LE6

  • Chr Location
    10q26.3; chr10:131900977-131971533 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    29
  • cDNA Data
    97
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 52432 NCBI Gene Model | MGI Sequence Detail 36714 C57BL/6J ±  kb
    transcript NM_001347618 RefSeq | MGI Sequence Detail 2178 ZRU/MplStud  
    polypeptide Q925E7 UniProt | EBI | MGI Sequence Detail 453 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013138 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
      (term hierarchy)
    • InterPro Domains
      IPR000009 Protein phosphatase 2A regulatory subunit PR55
      IPR018067 Protein phosphatase 2A regulatory subunit PR55, conserved site
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      Q925E7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 98
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915063
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:352604 Sanz-Flores M, et al., PP2A-B55 phosphatase counteracts Ki-67-dependent chromosome individualization during mitosis. Cell Rep. 2024 Jul 23;43(7):114494
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory