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Scyl2 Gene Detail
Summary
  • Symbol
    Scyl2
  • Name
    SCY1-like 2 (S. cerevisiae)
  • Synonyms
    CVAK104, D10Ertd802e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1289172
    NCBI Gene: 213326
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:89474583-89522147 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 45.05 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    442 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1289172
 protein coding gene Chr10:89474582-89522179 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017638
 protein coding gene Chr10:90832747-90882863 (-)
A/J MGP_AJ_G0017617
 protein coding gene Chr10:87728956-87776516 (-)
AKR/J MGP_AKRJ_G0017575
 protein coding gene Chr10:90218813-90267316 (-)
BALB/cJ MGP_BALBcJ_G0017580
 protein coding gene Chr10:87989182-88038327 (-)
C3H/HeJ MGP_C3HHeJ_G0017403
 protein coding gene Chr10:90226495-90275923 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018037
 protein coding gene Chr10:93870564-93926427 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015719
 protein coding gene Chr10:83438009-83486957 (-)
CAST/EiJ MGP_CASTEiJ_G0016968
 protein coding gene Chr10:90146627-90199512 (-)
CBA/J MGP_CBAJ_G0017372
 protein coding gene Chr10:97743398-97794604 (-)
DBA/2J MGP_DBA2J_G0017478
 protein coding gene Chr10:86847672-86895879 (-)
FVB/NJ MGP_FVBNJ_G0017470
 protein coding gene Chr10:86070371-86118486 (-)
LP/J MGP_LPJ_G0017552
 protein coding gene Chr10:91472341-91522583 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017501
 protein coding gene Chr10:99224520-99277873 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018074
 protein coding gene Chr10:90105024-90157493 (-)
PWK/PhJ MGP_PWKPhJ_G0016749
 protein coding gene Chr10:86876744-86926084 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016537
 protein coding gene Chr10:88857954-88907074 (-)
WSB/EiJ MGP_WSBEiJ_G0017027
 protein coding gene Chr10:90094196-90142558 (-)



Homology
more
  • Human Ortholog
    SCYL2, SCY1 like pseudokinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCYL2, SCY1 like pseudokinase 2
  • Synonyms
    AMC4, AMCNACC, CVAK104
  • Links
    NCBI Gene ID: 55681
    neXtProt AC: NX_Q6P3W7
    UniProt: Q6P3W7

  • Chr Location
    12q23.1; chr12:100267140-100341715 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SCYL2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, absent gastric milk in neonates, postnatal growth retardation, sensory-motor deficits and limb grapsing. Mice homozygous for a conditional allele exhibit similar phenotypes with near complete loss of CA3 neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    64
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000069539 Ensembl Gene Model | MGI Sequence Detail 47565 C57BL/6J ±  kb
    transcript ENSMUST00000174252 Ensembl | MGI Sequence Detail 4817 Not Applicable  
    polypeptide ENSMUSP00000133992 Ensembl | MGI Sequence Detail 930 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 66
      cDNA 65
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143723, MGI:2143847, MGI:2446127
    References
    more
    • Summaries
      All 39
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:225808 Gingras S, et al., SCYL2 Protects CA3 Pyramidal Neurons from Excitotoxicity during Functional Maturation of the Mouse Hippocampus. J Neurosci. 2015 Jul 22;35(29):10510-22
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory