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Coch Gene Detail
Summary
  • Symbol
    Coch
  • Name
    cochlin
  • Synonyms
    Coch-5B2, D12H14S564E
  • Feature Type
    protein coding gene
  • IDs
    MGI:1278313
    NCBI Gene: 12810
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:51640156-51652558 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 22.11 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    393 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1278313
 protein coding gene Chr12:51640124-51652558 (+)
129S1/SvImJ ENSMUSG00200028432
 protein coding gene Chr12:43598706-43611074 (+)
A/J ENSMUSG00195017587
 protein coding gene Chr12:46169171-46181603 (+)
AKR/J ENSMUSG00220025287
 protein coding gene Chr12:44207512-44219943 (+)
BALB/cJ ENSMUSG00180005874
 protein coding gene Chr12:45160920-45173353 (+)
C3H/HeJ ENSMUSG00175011521
 protein coding gene Chr12:48231538-48243969 (+)
C57BL/6NJ ENSMUSG00215010746
 protein coding gene Chr12:44555556-44567987 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017735
 protein coding gene Chr12:47011307-47023024 (+)
CAST/EiJ ENSTCUG00005008585
 protein coding gene Chr12:44725448-44737874 (+)
CBA/J ENSMUSG00210009219
 protein coding gene Chr12:44705927-44718358 (+)
DBA/2J ENSMUSG00185014138
 protein coding gene Chr12:46673393-46685822 (+)
FVB/NJ ENSMUSG00205013348
 protein coding gene Chr12:44496322-44508753 (+)
JF1/MsJ ENSUMUG00000007258
 protein coding gene Chr12:50822026-50834394 (+)
LP/J ENSMUSG00230015468
 protein coding gene Chr12:53706113-53718480 (+)
NOD/ShiLtJ ENSMUSG00190016002
 protein coding gene Chr12:43696304-43708734 (+)
NZO/HlLtJ ENSMUSG00225040893
 protein coding gene Chr12:55842574-55855005 (+)
PWK/PhJ ENSLUMG00010016395
 protein coding gene Chr12:44890676-44903047 (+)
SPRET/EiJ ENSMSPG00010015396
 protein coding gene Chr12:46209468-46221882 (+)
WSB/EiJ ENSIUOG00005003393
 protein coding gene Chr12:44527580-44539983 (+)



Homology
more
  • Human Ortholog
    COCH, cochlin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COCH, cochlin
  • Synonyms
    COCH-5B2, COCH5B2, DFNA9, DFNB110
  • Links
    NCBI Gene ID: 1690
    UniProt: O43405

  • Chr Location
    14q12; chr14:30874438-30895615 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Coch mouse models; 2 with human COCH associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 5 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a point mutation have vestibular and hearing dysfunctions that worsen with age. Homozyogtes for a null allele have no abnormal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    704
  • Tissues
    34
  • cDNA Data
    15
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12810 NCBI Gene Model | MGI Sequence Detail 12403 C57BL/6J ±  kb
    transcript NM_007728 RefSeq | MGI Sequence Detail 2653 ZRU/MplStud  
    polypeptide Q62507 UniProt | EBI | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 1
      Other 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2145007
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:39118 Crozet F, et al., Cloning of the genes encoding two murine and human cochlear unconventional type I myosins. Genomics. 1997 Mar 1;40(2):332-41
    • Latest
      J:363936 Zhang H, et al., Kolliker's Organ Functions as a Developmental Hub in Mouse Cochlea Regulating Spiral Limbus and Tectorial Membrane Development. J Neurosci. 2025 Mar 26;45(13)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory