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Fgf18 Gene Detail
Summary
  • Symbol
    Fgf18
  • Name
    fibroblast growth factor 18
  • Synonyms
    D130055P09Rik, FGF-18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277980
    NCBI Gene: 14172
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:33067430-33097400 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 19.21 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277980
 protein coding gene Chr11:33066970-33097400 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018140
 protein coding gene Chr11:31394071-31425858 (-)
A/J MGP_AJ_G0018113
 protein coding gene Chr11:30200283-30229806 (-)
AKR/J MGP_AKRJ_G0018077
 protein coding gene Chr11:31148483-31177980 (-)
BALB/cJ MGP_BALBcJ_G0018082
 protein coding gene Chr11:30376461-30405866 (-)
C3H/HeJ MGP_C3HHeJ_G0017895
 protein coding gene Chr11:31091148-31120640 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018536
 protein coding gene Chr11:32425690-32455192 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016191
 protein coding gene Chr11:28704324-28734390 (-)
CAST/EiJ MGP_CASTEiJ_G0017459
 protein coding gene Chr11:31134807-31189652 (-)
CBA/J MGP_CBAJ_G0017868
 protein coding gene Chr11:33973779-34003762 (-)
DBA/2J MGP_DBA2J_G0017978
 protein coding gene Chr11:29973315-30002828 (-)
FVB/NJ MGP_FVBNJ_G0017972
 protein coding gene Chr11:29804760-29834835 (-)
LP/J MGP_LPJ_G0018050
 protein coding gene Chr11:31660839-31690331 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017996
 protein coding gene Chr11:34919952-34953946 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018575
 protein coding gene Chr11:31293106-31322548 (-)
PWK/PhJ MGP_PWKPhJ_G0017240
 protein coding gene Chr11:30127681-30181006 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017032
 protein coding gene Chr11:31006418-31038284 (-)
WSB/EiJ MGP_WSBEiJ_G0017508
 protein coding gene Chr11:30913420-30942931 (-)



Homology
more
  • Human Ortholog
    FGF18, fibroblast growth factor 18
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF18, fibroblast growth factor 18
  • Synonyms
    FGF-18, ZFGF5
  • Links
    NCBI Gene ID: 8817
    neXtProt AC: NX_O76093
    UniProt: O76093

  • Chr Location
    5q35.1; chr5:171419647-171457626 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 3 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die perinatally and exhibit impaired proliferation and differentiation of osteoblasts, shortened and thickened long bones, and delayed ossification of the calvarium and long bones.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1157
  • Tissues
    248
  • cDNA Data
    11
  • Literature Summary
    91
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057967 Ensembl Gene Model | MGI Sequence Detail 29971 C57BL/6J ±  kb
    transcript ENSMUST00000020507 Ensembl | MGI Sequence Detail 1086 Not Applicable  
    polypeptide ENSMUSP00000020507 Ensembl | MGI Sequence Detail 207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 13
      Primer pair 13
      Other 14

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2441946
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 91
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:341716 Tsuchiya Y, et al., Fibroblast growth factor 18 stimulates the proliferation of hepatic stellate cells, thereby inducing liver fibrosis. Nat Commun. 2023 Oct 9;14(1):6304
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory