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Ehhadh Gene Detail
Summary
  • Symbol
    Ehhadh
  • Name
    enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase
  • Synonyms
    1300002P22Rik, HD, L-bifunctional enzyme, L-PBE, MFP, MFP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1277964
    NCBI Gene: 74147
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:21580037-21606557 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 12.86 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    152 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1277964
 protein coding gene Chr16:21580035-21606589 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022661
 protein coding gene Chr16:19195841-19224859 (-)
A/J MGP_AJ_G0022623
 protein coding gene Chr16:18284763-18311267 (-)
AKR/J MGP_AKRJ_G0022598
 protein coding gene Chr16:19052051-19080377 (-)
BALB/cJ MGP_BALBcJ_G0022627
 protein coding gene Chr16:18478122-18509053 (-)
C3H/HeJ MGP_C3HHeJ_G0022392
 protein coding gene Chr16:19148527-19179702 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023078
 protein coding gene Chr16:19606476-19634629 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020596
 protein coding gene Chr16:18981441-19006738 (-)
CAST/EiJ MGP_CASTEiJ_G0021922
 protein coding gene Chr16:19140313-19167657 (-)
CBA/J MGP_CBAJ_G0022364
 protein coding gene Chr16:20428446-20460942 (-)
DBA/2J MGP_DBA2J_G0022496
 protein coding gene Chr16:18269419-18295867 (-)
FVB/NJ MGP_FVBNJ_G0022471
 protein coding gene Chr16:18238345-18264595 (-)
LP/J MGP_LPJ_G0022563
 protein coding gene Chr16:18948919-18977735 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022491
 protein coding gene Chr16:20021033-20060832 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023089
 protein coding gene Chr16:18994263-19021057 (-)
PWK/PhJ MGP_PWKPhJ_G0021662
 protein coding gene Chr16:18499892-18528906 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021492
 protein coding gene Chr16:18771595-18800770 (-)
WSB/EiJ MGP_WSBEiJ_G0021965
 protein coding gene Chr16:18959578-18987610 (-)



Homology
more
  • Human Ortholog
    EHHADH, enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EHHADH, enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
  • Synonyms
    ECHD, FRTS3, LBFP, LBP, L-PBE, MFE1, PBFE
  • Links
    NCBI Gene ID: 1962
    neXtProt AC: NX_Q08426
    UniProt: Q08426

  • Chr Location
    3q27.2; chr3:185190624-185281990 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EHHADH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    3 images
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruption of this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    926
  • Tissues
    140
  • cDNA Data
    84
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022853 Ensembl Gene Model | MGI Sequence Detail 26521 C57BL/6J ±  kb
    transcript ENSMUST00000023559 Ensembl | MGI Sequence Detail 2981 Not Applicable  
    polypeptide ENSMUSP00000023559 Ensembl | MGI Sequence Detail 718 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 84
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1921397
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 13
      Diseases 2
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:55395 Qi C, et al., Absence of spontaneous peroxisome proliferation in enoyl-CoA Hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism. J Biol Chem. 1999 May 28;274(22):15775-80
    • Latest
      J:326089 Ghnaimawi S, et al., The Effects of Maternal Intake of EPA and DHA Enriched Diet During Pregnancy and Lactation on Offspring's Muscle Development and Energy Homeostasis. Front Physiol. 2022;13:881624
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory