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Ttc3 Gene Detail
Summary
  • Symbol
    Ttc3
  • Name
    tetratricopeptide repeat domain 3
  • Synonyms
    2610202A04Rik, D16Ium21, D16Ium21e, TPRD
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276539
    NCBI Gene: 22129
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:94171479-94270081 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 55.18 cM, cytoband C3.3-4
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    761 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276539
 protein coding gene Chr16:94171477-94270202 (+)
129S1/SvImJ ENSMUSG00200037277
 protein coding gene Chr16:91156695-91160384 (+)
129S1/SvImJ ENSMUSGG00200054668
 protein coding gene Chr16:91109060-91156709 (+)
A/J ENSMUSG00195026500
 protein coding gene Chr16:90908760-90912449 (+)
A/J ENSMUSGG00195054971
 protein coding gene Chr16:90860911-90908774 (+)
AKR/J ENSMUSGG00220054747
 protein coding gene Chr16:91105842-91153481 (+)
AKR/J ENSMUSG00220015988
 protein coding gene Chr16:91153467-91157156 (+)
BALB/cJ ENSMUSG00180014719
 protein coding gene Chr16:90982920-90986609 (+)
BALB/cJ ENSMUSGG00180055300
 protein coding gene Chr16:90934887-90982934 (+)
C3H/HeJ ENSMUSGG00175054980
 protein coding gene Chr16:91271988-91319845 (+)
C3H/HeJ ENSMUSG00175014604
 protein coding gene Chr16:91319831-91323520 (+)
C57BL/6NJ ENSMUSG00215018624
 protein coding gene Chr16:91111352-91115041 (+)
C57BL/6NJ ENSMUSGG00215055468
 protein coding gene Chr16:91063507-91111366 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020990
 protein coding gene Chr16:88970143-89071608 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210033690
 protein coding gene Chr16:91226800-91230489 (+)
CBA/J ENSMUSGG00210054801
 protein coding gene Chr16:91179176-91226814 (+)
DBA/2J ENSMUSGG00185057659
 protein coding gene Chr16:91118912-91166773 (+)
DBA/2J ENSMUSG00185029895
 protein coding gene Chr16:91166759-91170448 (+)
FVB/NJ ENSMUSG00205013646
 protein coding gene Chr16:90945762-90949451 (+)
FVB/NJ ENSMUSGG00205054296
 protein coding gene Chr16:90898129-90945776 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055328
 protein coding gene Chr16:93655655-93703301 (+)
LP/J ENSMUSG00230025684
 protein coding gene Chr16:93703287-93706976 (+)
NOD/ShiLtJ ENSMUSG00190020270
 protein coding gene Chr16:91134697-91138386 (+)
NOD/ShiLtJ ENSMUSGG00190054763
 protein coding gene Chr16:91087065-91134711 (+)
NZO/HlLtJ ENSMUSG00225030168
 protein coding gene Chr16:96812503-96816192 (+)
NZO/HlLtJ ENSMUSGG00225055217
 protein coding gene Chr16:96764873-96812517 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010020075
 protein coding gene Chr16:92024055-92123403 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    TTC3, tetratricopeptide repeat domain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TTC3, tetratricopeptide repeat domain 3
  • Synonyms
    DCRR1, RNF105, TPRDIII
  • Links
    NCBI Gene ID: 7267
    UniProt: P53804

  • Chr Location
    21q22.13; chr21:37073226-37203118 (+)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    98 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    911
  • Tissues
    220
  • cDNA Data
    38
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 22129 NCBI Gene Model | MGI Sequence Detail 98603 C57BL/6J ±  kb
transcript NM_009441 RefSeq | MGI Sequence Detail 7295 Not Specified  
polypeptide O88196 UniProt | EBI | MGI Sequence Detail 1979 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 49
    Genomic 3
    cDNA 40
    Primer pair 4
    Other 2

    Microarray probesets 9
Other
Accession IDs
less
MGD-MRK-33853, MGI:106166, MGI:1917694, MGI:2146340
References
more
  • Summaries
    All 143
    Developmental Gene Expression 10
    Diseases 6
    Gene Ontology 9
    Phenotypes 98
  • Earliest
    J:34963 Wei J, et al., Direct cDNA selection with DNA microdissected from mouse chromosome 16: isolation of novel clones and construction of a partial transcription map of the C3-C4 region. Genome Res. 1996 Aug;6(8):678-87
  • Latest
    J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory