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Taldo1 Gene Detail
Summary
  • Symbol
    Taldo1
  • Name
    transaldolase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1274789
    NCBI Gene: 21351
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:140972112-140982881 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.73 cM, cytoband F3-F4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1274789
 protein coding gene Chr7:140972073-140982889 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033226
 protein coding gene Chr7:146578832-146590245 (+)
A/J MGP_AJ_G0033208
 protein coding gene Chr7:142385548-142396283 (+)
AKR/J MGP_AKRJ_G0033140
 protein coding gene Chr7:146318989-146332295 (+)
BALB/cJ MGP_BALBcJ_G0033209
 protein coding gene Chr7:142131039-142142379 (+)
C3H/HeJ MGP_C3HHeJ_G0032923
 protein coding gene Chr7:146076639-146087511 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033720
 protein coding gene Chr7:151930208-151942087 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030693
 protein coding gene Chr7:143600678-143611074 (+)
CAST/EiJ MGP_CASTEiJ_G0032253
 protein coding gene Chr7:138384450-138396842 (+)
CBA/J MGP_CBAJ_G0032895
 protein coding gene Chr7:157087145-157097943 (+)
DBA/2J MGP_DBA2J_G0033047
 protein coding gene Chr7:140333739-140345297 (+)
FVB/NJ MGP_FVBNJ_G0033000
 protein coding gene Chr7:140248399-140260478 (+)
LP/J MGP_LPJ_G0033142
 protein coding gene Chr7:148075561-148086996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033033
 protein coding gene Chr7:157725233-157736746 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033740
 protein coding gene Chr7:145292242-145303677 (+)
PWK/PhJ MGP_PWKPhJ_G0031957
 protein coding gene Chr7:133615175-133627041 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031804
 protein coding gene Chr7:132116569-132136269 (+)
WSB/EiJ MGP_WSBEiJ_G0032364
 protein coding gene Chr7:146240845-146252745 (+)



Homology
more
  • Human Ortholog
    TALDO1, transaldolase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TALDO1, transaldolase 1
  • Synonyms
    TAL, TALDOR, TALH, TAL-H
  • Links
    NCBI Gene ID: 6888
    neXtProt AC: NX_P37837
    UniProt: P37837

  • Chr Location
    11p15.5; chr11:747415-765012 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TALDO1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in male infertility due to defective sperm motility because of functional and structural defects of mitochondria in the sperm. Heterozygous mice show reduced male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    400
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025503 Ensembl Gene Model | MGI Sequence Detail 10770 C57BL/6J ±  kb
    transcript ENSMUST00000211654 Ensembl | MGI Sequence Detail 1362 Not Applicable  
    polypeptide ENSMUSP00000147332 Ensembl | MGI Sequence Detail 382 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 400
      cDNA 400

      Microarray probesets 3
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:322975 HIATT HH, Glycogen formation via the pentose phosphate pathway in mice in vivo. J Biol Chem. 1957 Feb;224(2):851-9
    • Latest
      J:338387 Oaks Z, et al., Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis. Nat Metab. 2023 Jan;5(1):41-60
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/30/2024
    MGI 6.23     		The Jackson Laboratory