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Plscr2 Gene Detail
Summary
  • Symbol
    Plscr2
  • Name
    phospholipid scramblase 2
  • Synonyms
    PL scramblase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1270860
    NCBI Gene: 18828
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:92157655-92179805 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 48.35 cM, cytoband E3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    889 from dbSNP Build 142
  • Strain Annotations
    22
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1270860
 protein coding gene Chr9:92157655-92179805 (+)
129S1/SvImJ ENSMUSG00200005073
 protein coding gene Chr9:89288996-89289076 (+)
129S1/SvImJ ENSMUSGG00200054946
 protein coding gene Chr9:89297515-89304608 (+)
A/J ENSMUSG00195007003
 protein coding gene Chr9:88543621-88559253 (+)
AKR/J ENSMUSG00220019666
 protein coding gene Chr9:88924193-88924273 (+)
AKR/J ENSMUSGG00220054720
 protein coding gene Chr9:88932712-88939803 (+)
BALB/cJ ENSMUSG00180007044
 protein coding gene Chr9:88869356-88884984 (+)
C3H/HeJ ENSMUSG00175004382
 protein coding gene Chr9:89180746-89196372 (+)
C57BL/6NJ ENSMUSG00215008117
 protein coding gene Chr9:89176374-89176454 (+)
C57BL/6NJ ENSMUSGG00215055608
 protein coding gene Chr9:89184895-89191987 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032524
 protein coding gene Chr9:88104569-88128662 (+)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054972
 protein coding gene Chr9:89057088-89057168 (+)
DBA/2J ENSMUSG00185001658
 protein coding gene Chr9:89246704-89262316 (+)
FVB/NJ ENSMUSG00205004558
 protein coding gene Chr9:89382619-89382699 (+)
FVB/NJ ENSMUSGG00205054055
 protein coding gene Chr9:89391141-89398232 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055709
 protein coding gene Chr9:89403508-89410600 (+)
LP/J ENSMUSG00230008315
 protein coding gene Chr9:89394987-89395067 (+)
NOD/ShiLtJ ENSMUSG00190010775
 protein coding gene Chr9:88838773-88854386 (+)
NZO/HlLtJ ENSMUSGG00225055529
 protein coding gene Chr9:89543876-89543956 (+)
PWK/PhJ ENSLUMG00010002919
 protein coding gene Chr9:88929026-88944605 (+)
SPRET/EiJ ENSMSPG00010002247
 protein coding gene Chr9:90681144-90704966 (+)
WSB/EiJ ENSIUOG00005003558
 protein coding gene Chr9:88299662-88315302 (+)



Homology
more
  • Human Ortholog
    PLSCR1, phospholipid scramblase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLSCR1, phospholipid scramblase 1
  • Synonyms
    MMTRA1B
  • Links
    NCBI Gene ID: 5359
    UniProt: O15162

  • Chr Location
    3q24; chr3:146511858-146544862 (-)  GRCh38
  • Human Ortholog
    PLSCR2, phospholipid scramblase 2
  • Links
    NCBI Gene ID: 57047
    UniProt: Q9NRY7

  • Chr Location
    3q24; chr3:146391420-146495991 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    654
  • Tissues
    6
  • cDNA Data
    63
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 18828 NCBI Gene Model | MGI Sequence Detail 22151 C57BL/6J ±  kb
transcript NM_001195084 RefSeq | MGI Sequence Detail 1900 C57BL/6  
polypeptide Q9DCW2 UniProt | EBI | MGI Sequence Detail 307 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR005552 Scramblase
Molecular
Reagents
less
  • All nucleic 63
    cDNA 63

    Microarray probesets 3
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 10
    Phenotypes 9
  • Earliest
    J:46122 Zhou Q, et al., Identity of a conserved motif in phospholipid scramblase that is required for Ca2+-accelerated transbilayer movement of membrane phospholipids. Biochemistry. 1998 Feb 24;37(8):2356-60
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory