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Mcpt8 Gene Detail
Summary
  • Symbol
    Mcpt8
  • Name
    mast cell protease 8
  • Synonyms
    MMCP-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261780
    NCBI Gene: 17231
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56319623-56322730 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    177 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261780
 protein coding gene Chr14:56319620-56322951 (-)
129S1/SvImJ ENSMUSG00200040902
 protein coding gene Chr14:44907406-44910508 (-)
A/J ENSMUSG00195029256
 protein coding gene Chr14:45124152-45127259 (-)
AKR/J ENSMUSG00220025789
 protein coding gene Chr14:44452014-44455121 (-)
BALB/cJ ENSMUSG00180048893
 protein coding gene Chr14:44747829-44750936 (-)
C3H/HeJ ENSMUSG00175046352
 protein coding gene Chr14:46430151-46433258 (-)
C57BL/6NJ ENSMUSG00215048241
 protein coding gene Chr14:44642902-44646009 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019327
 protein coding gene Chr14:47375179-47378204 (-)
CAST/EiJ ENSTCUG00005047227
 protein coding gene Chr14:46415873-46418982 (-)
CBA/J ENSMUSG00210039819
 protein coding gene Chr14:45110712-45113819 (-)
DBA/2J ENSMUSG00185052914
 protein coding gene Chr14:50232186-50235302 (-)
FVB/NJ ENSMUSG00205035659
 protein coding gene Chr14:44513522-44516618 (-)
JF1/MsJ ENSUMUG00000023519
 protein coding gene Chr14:61410069-61413159 (-)
LP/J ENSMUSG00230052174
 protein coding gene Chr14:62273245-62276347 (-)
NOD/ShiLtJ ENSMUSG00190033886
 protein coding gene Chr14:44876871-44879967 (-)
NZO/HlLtJ ENSMUSG00225045884
 protein coding gene Chr14:52563598-52566705 (-)
PWK/PhJ ENSLUMG00010043944
 protein coding gene Chr14:44333327-44336434 (-)
SPRET/EiJ ENSMSPG00010044802
 protein coding gene Chr14:47830532-47833608 (-)
WSB/EiJ ENSIUOG00005041556
 protein coding gene Chr14:44308716-44311807 (-)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from multigenic genotypes
    50 phenotype references
Mice homozygous for a knock-in mutation that allows diphtheria toxin-mediated basophil depletion before the second tick infestation exhibit loss of acquired tick resistance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    624
  • Tissues
    2
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022157 Ensembl Gene Model | MGI Sequence Detail 3108 C57BL/6J ±  kb
transcript ENSMUST00000015594 Ensembl | MGI Sequence Detail 836 Not Applicable  
polypeptide ENSMUSP00000015594 Ensembl | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 9
    cDNA 8
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145855
References
more
  • Summaries
    All 83
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 50
  • Earliest
    J:46663 Lutzelschwab C, et al., Characterization of mouse mast cell protease-8, the first member of a novel subfamily of mouse mast cell serine proteases, distinct from both the classical chymases and tryptases. Eur J Immunol. 1998 Mar;28(3):1022-33
  • Latest
    J:390799 Bex J, et al., Basophils drive the resolution and promote wound healing in adult and aged mice. J Exp Med. 2026 May 4;223(5)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory