About   Help   FAQ
Kcnu1 Gene Detail
Summary
  • Symbol
    Kcnu1
  • Name
    potassium channel, subfamily U, member 1
  • Synonyms
    Kcnma3, Slo3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1202300
    NCBI Gene: 16532
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:26339651-26427967 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 14.17 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1202300
 protein coding gene Chr8:26338656-26427971 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033491
 protein coding gene Chr8:23923114-24013285 (+)
A/J MGP_AJ_G0033471
 protein coding gene Chr8:23053834-23137767 (+)
AKR/J MGP_AKRJ_G0033396
 protein coding gene Chr8:23817639-23906770 (+)
BALB/cJ MGP_BALBcJ_G0033467
 protein coding gene Chr8:23200432-23288047 (+)
C3H/HeJ MGP_C3HHeJ_G0033181
 protein coding gene Chr8:24023709-24118549 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033983
 protein coding gene Chr8:24890953-24993891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030933
 protein coding gene Chr8:20321718-20410703 (+)
CAST/EiJ MGP_CASTEiJ_G0032507
 protein coding gene Chr8:23471598-23563727 (+)
CBA/J MGP_CBAJ_G0033156
 protein coding gene Chr8:25867818-25963850 (+)
DBA/2J MGP_DBA2J_G0033311
 protein coding gene Chr8:23023483-23107653 (+)
FVB/NJ MGP_FVBNJ_G0033255
 protein coding gene Chr8:22829391-22918309 (+)
LP/J MGP_LPJ_G0033400
 protein coding gene Chr8:23898121-23988864 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033298
 protein coding gene Chr8:25320452-25421651 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034002
 protein coding gene Chr8:23750876-23834851 (+)
PWK/PhJ MGP_PWKPhJ_G0032218
 protein coding gene Chr8:22664463-22749423 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032052
 protein coding gene Chr8:23125256-23222076 (+)
WSB/EiJ MGP_WSBEiJ_G0032623
 protein coding gene Chr8:23968984-24056666 (+)



Homology
more
  • Human Ortholog
    KCNU1, potassium calcium-activated channel subfamily U member 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNU1, potassium calcium-activated channel subfamily U member 1
  • Synonyms
    KCa5, KCa5.1, Kcnma3, KCNMC1, Slo3, SPGF79
  • Links
    NCBI Gene ID: 157855
    neXtProt AC: NX_A8MYU2
    UniProt: A8MYU2

  • Chr Location
    8p11.23; chr8:36784324-36936125 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human KCNU1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous male mutants are infertile with impaired sperm capacitation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031576 Ensembl Gene Model | MGI Sequence Detail 88317 C57BL/6J ±  kb
    transcript ENSMUST00000098858 Ensembl | MGI Sequence Detail 3536 Not Applicable  
    polypeptide ENSMUSP00000096457 Ensembl | MGI Sequence Detail 1121 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000009271 potassium channel subfamily U member 1
      (term hierarchy)
    • InterPro Domains
      IPR048735 Ca2+-activated K+ channel Slowpoke-like, C-terminal domain
      IPR003929 Calcium-activated potassium channel BK, alpha subunit
      IPR047871 Calcium-activated potassium channel slowpoke-like
      IPR005821 Ion transport domain
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 3
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:45626 Schreiber M, et al., Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes. J Biol Chem. 1998 Feb 6;273(6):3509-16
    • Latest
      J:298992 Balbach M, et al., Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm. Front Cell Dev Biol. 2020;8:572735
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory