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Pitpnm1 Gene Detail
Summary
  • Symbol
    Pitpnm1
  • Name
    phosphatidylinositol transfer protein, membrane-associated 1
  • Synonyms
    DRES9, RdgB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197524
    NCBI Gene: 18739
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4150012-4163966 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 3.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197524
 protein coding gene Chr19:4149998-4163966 (+)
129S1/SvImJ ENSMUSG00200050573
 protein coding gene Chr19:911144-924488 (+)
A/J ENSMUSG00195051701
 protein coding gene Chr19:1302363-1315705 (+)
AKR/J ENSMUSG00220039504
 protein coding gene Chr19:1075321-1088662 (+)
BALB/cJ ENSMUSG00180044688
 protein coding gene Chr19:1677125-1690465 (+)
C3H/HeJ ENSMUSG00175009434
 protein coding gene Chr19:921840-935182 (+)
C57BL/6NJ ENSMUSG00215043252
 protein coding gene Chr19:1149443-1162787 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022489
 protein coding gene Chr19:843251-857895 (+)
CAST/EiJ ENSTCUG00005026319
 protein coding gene Chr19:1056492-1069815 (+)
CBA/J ENSMUSG00210048155
 protein coding gene Chr19:922168-935508 (+)
DBA/2J ENSMUSG00185039919
 protein coding gene Chr19:1298479-1311819 (+)
FVB/NJ ENSMUSG00205041343
 protein coding gene Chr19:1299668-1313015 (+)
JF1/MsJ ENSUMUG00000053343
 protein coding gene Chr19:1283562-1296884 (+)
LP/J ENSMUSG00230051942
 protein coding gene Chr19:2217308-2230652 (+)
NOD/ShiLtJ ENSMUSG00190028610
 protein coding gene Chr19:843472-856812 (+)
NZO/HlLtJ ENSMUSG00225025571
 protein coding gene Chr19:5926153-5939497 (+)
PWK/PhJ ENSLUMG00010005351
 protein coding gene Chr19:1060146-1073627 (+)
SPRET/EiJ ENSMSPG00010038711
 protein coding gene Chr19:1039949-1053819 (+)
WSB/EiJ ENSIUOG00005045443
 protein coding gene Chr19:927637-940976 (+)



Homology
more
  • Human Ortholog
    PITPNM1, phosphatidylinositol transfer protein membrane associated 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PITPNM1, phosphatidylinositol transfer protein membrane associated 1
  • Synonyms
    DRES9, NIR2, PITPNM, Rd9, RDGB, RDGB1, RDGBA, RDGBA1
  • Links
    NCBI Gene ID: 9600
    UniProt: O00562

  • Chr Location
    11q13.2; chr11:67491760-67506266 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit male-specific decrease in circulating cholesterol and circulating calcium levels and female-specific decreased leukocyte cell numbers and a slight increase in auditory brainstem response.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    56
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    90
  • cDNA Data
    110
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18739 NCBI Gene Model | MGI Sequence Detail 13955 C57BL/6J ±  kb
    transcript NM_008851 RefSeq | MGI Sequence Detail 4533 ZRU/MplStud  
    polypeptide O35954 UniProt | EBI | MGI Sequence Detail 1243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 110
      Primer pair 2
      Other 3
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1097685, MGI:2147812
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 8
    • Earliest
      J:41770 Chang JT, et al., Mammalian homolog of Drosophila retinal degeneration B rescues the mutant fly phenotype. J Neurosci. 1997 Aug 1;17(15):5881-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory