About   Help   FAQ
Limk2 Gene Detail
Summary
  • Symbol
    Limk2
  • Name
    LIM domain kinase 2
  • Synonyms
    A930024P04Rik, Limk2a, Limk2b, LIM kinase 2, whe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197517
    NCBI Gene: 16886
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3294256-3359189 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.34 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1471 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197517
 protein coding gene Chr11:3293297-3359238 (-)
129S1/SvImJ ENSMUSG00200031214
 protein coding gene Chr11:247316-312200 (-)
A/J ENSMUSG00195022756
 protein coding gene Chr11:154617-219556 (-)
AKR/J ENSMUSG00220008306
 protein coding gene Chr11:167723-232665 (-)
BALB/cJ ENSMUSG00180024020
 protein coding gene Chr11:177572-242515 (-)
C3H/HeJ ENSMUSG00175009353
 protein coding gene Chr11:167373-232297 (-)
C57BL/6NJ ENSMUSG00215027962
 protein coding gene Chr11:177691-242619 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016009
 protein coding gene Chr11:174819-240771 (-)
CAST/EiJ ENSTCUG00005035796
 protein coding gene Chr11:262275-328344 (-)
CBA/J ENSMUSG00210017632
 protein coding gene Chr11:167126-232047 (-)
DBA/2J ENSMUSG00185016498
 protein coding gene Chr11:264733-329653 (-)
FVB/NJ ENSMUSG00205029167
 protein coding gene Chr11:138057-202986 (-)
JF1/MsJ ENSUMUG00000043149
 protein coding gene Chr11:410680-484981 (-)
LP/J ENSMUSG00230031573
 protein coding gene Chr11:1330546-1395429 (-)
NOD/ShiLtJ ENSMUSG00190028704
 protein coding gene Chr11:154541-219478 (-)
NZO/HlLtJ ENSMUSG00225025321
 protein coding gene Chr11:3387483-3452434 (-)
PWK/PhJ ENSLUMG00010017702
 protein coding gene Chr11:155701-221301 (-)
SPRET/EiJ ENSMSPG00010008358
 protein coding gene Chr11:239710-305587 (-)
WSB/EiJ ENSIUOG00005007087
 protein coding gene Chr11:168424-233368 (-)



Homology
more
  • Human Ortholog
    LIMK2, LIM domain kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIMK2, LIM domain kinase 2
  • Links
    NCBI Gene ID: 3985
    UniProt: P53671

  • Chr Location
    22q12.2; chr22:31212193-31280964 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 4 genetic backgrounds
    2 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male homozygotes for targeted null mutations exhibit small testes but are fertile. Mutant kidneys have fewer glomeruli and dilated renal tubules, but function normally. Mice homozygous for a gene trap allele or spontaneous mutation have open eyelids at birth, corneal abnormalities and inflammation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    930
  • Tissues
    136
  • cDNA Data
    24
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020451 Ensembl Gene Model | MGI Sequence Detail 64934 C57BL/6J ±  kb
    transcript ENSMUST00000101638 Ensembl | MGI Sequence Detail 3514 Not Applicable  
    polypeptide ENSMUSP00000099162 Ensembl | MGI Sequence Detail 638 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 7
      cDNA 25
      Primer pair 4
      Other 1
      Antibodies 6

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144678, MGI:2443338, MGI:3612834
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 19
      Gene Ontology 13
      Phenotypes 25
    • Earliest
      J:101797 Casola S, et al., Loss of heterozygosity of imprinted genes in SV40 t/T antigen-induced hepatocellular carcinomas. Oncogene. 1995 Aug 17;11(4):711-21
    • Latest
      J:372888 Tian J, et al., LIMK2 promotes centrosome clustering and cancer progression by activating MST4-mediated phosphorylation of NPM1. Oncogene. 2025 Oct;44(38):3625-3639
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory