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Kcns1 Gene Detail
Summary
  • Symbol
    Kcns1
  • Name
    K+ voltage-gated channel, subfamily S, 1
  • Synonyms
    Kv9.1
Location &
Maps
more
  • Sequence Map
    Chr2:164005539-164013033 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 84.60 cM, cytoband H3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    366 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1197019
 protein coding gene Chr2:164005539-164013865 (-)
129S1/SvImJ ENSMUSG00200016481
 protein coding gene Chr2:160877603-160885089 (-)
A/J ENSMUSG00195016659
 protein coding gene Chr2:161219096-161226587 (-)
AKR/J ENSMUSG00220013261
 protein coding gene Chr2:160546542-160554035 (-)
BALB/cJ ENSMUSG00180043384
 protein coding gene Chr2:160672843-160680334 (-)
C3H/HeJ ENSMUSG00175045565
 protein coding gene Chr2:161422616-161430108 (-)
C57BL/6NJ ENSMUSG00215019745
 protein coding gene Chr2:160875890-160883384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024630
 protein coding gene Chr2:155999146-156006688 (-)
CAST/EiJ ENSTCUG00005045134
 protein coding gene Chr2:159784348-159791870 (-)
CBA/J ENSMUSG00210016710
 protein coding gene Chr2:161353594-161361085 (-)
DBA/2J ENSMUSG00185047763
 protein coding gene Chr2:161089814-161097306 (-)
FVB/NJ ENSMUSG00205022579
 protein coding gene Chr2:160111037-160118531 (-)
JF1/MsJ ENSUMUG00000010190
 protein coding gene Chr2:160735297-160742837 (-)
LP/J ENSMUSG00230044607
 protein coding gene Chr2:162647221-162654707 (-)
NOD/ShiLtJ ENSMUSG00190039792
 protein coding gene Chr2:160758391-160765896 (-)
NZO/HlLtJ ENSMUSG00225052466
 protein coding gene Chr2:170652164-170659656 (-)
PWK/PhJ ENSLUMG00010046906
 protein coding gene Chr2:160639435-160646942 (-)
SPRET/EiJ ENSMSPG00010027915
 protein coding gene Chr2:163404450-163410001 (-)
WSB/EiJ ENSIUOG00005040707
 protein coding gene Chr2:160484499-160491989 (-)



Homology
more
  • Human Ortholog
    KCNS1, potassium voltage-gated channel modifier subfamily S member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNS1, potassium voltage-gated channel modifier subfamily S member 1
  • Synonyms
    hKv9.1, Kv9.1
  • Links
    NCBI Gene ID: 3787
    UniProt: Q96KK3

  • Chr Location
    20q13.12; chr20:45091214-45101127 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in DRG exhibit increased sensitivity to mechanical stimulation prior to and following neuropathic pain induction and cold nociception following neuropathic pain induction, and increased performance on a rotarod.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    3
  • cDNA Data
    10
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040164 Ensembl Gene Model | MGI Sequence Detail 7495 C57BL/6J ±  kb
transcript ENSMUST00000045196 Ensembl | MGI Sequence Detail 2712 Not Applicable  
polypeptide ENSMUSP00000038901 Ensembl | MGI Sequence Detail 497 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:43210 Salinas M, et al., New modulatory alpha subunits for mammalian Shab K+ channels. J Biol Chem. 1997 Sep 26;272(39):24371-9
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory