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Tcea1 Gene Detail
Summary
  • Symbol
    Tcea1
  • Name
    transcription elongation factor A (SII) 1
  • Synonyms
    S-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196624
    NCBI Gene: 21399
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:4928037-4968132 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 1.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1103 from dbSNP Build 142
  • Strain Annotations
    21
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196624
 protein coding gene Chr1:4927917-4968132 (+)
129S1/SvImJ ENSMUSG00200002572
 protein coding gene Chr1:2339090-2379185 (+)
A/J ENSMUSG00195002530
 protein coding gene Chr1:2133266-2173352 (+)
AKR/J ENSMUSG00220003115
 protein coding gene Chr1:2236044-2276145 (+)
BALB/cJ ENSMUSG00180008745
 protein coding gene Chr1:2203010-2243095 (+)
C3H/HeJ ENSMUSG00175000272
 protein coding gene Chr1:2066717-2106737 (+)
C57BL/6NJ ENSMUSG00215004093
 protein coding gene Chr1:2114341-2154439 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0013925
 protein coding gene Chr1:1644531-1678218 (+)
CAST/EiJ ENSTCUG00005001764
 protein coding gene Chr1:2480245-2520258 (+)
CBA/J ENSMUSG00210001786
 protein coding gene Chr1:1990647-2030641 (+)
DBA/2J ENSMUSG00185004200
 protein coding gene Chr1:3048885-3088912 (+)
FVB/NJ ENSMUSG00205004505
 protein coding gene Chr1:2267651-2307741 (+)
JF1/MsJ ENSUMUG00000003295
 protein coding gene Chr1:2324838-2360516 (+)
LP/J ENSMUSG00230001779
 protein coding gene Chr1:3039448-3079547 (+)
LP/J ENSMUSG00230006343
 protein coding gene Chr13:13086711-13089268 (+)
NOD/ShiLtJ ENSMUSG00190001006
 protein coding gene Chr1:2131956-2172056 (+)
NZO/HlLtJ ENSMUSG00225033949
 protein coding gene Chr13:6991973-6994530 (+)
NZO/HlLtJ ENSMUSG00225000088
 protein coding gene Chr1:6407410-6447500 (+)
PWK/PhJ ENSLUMG00010002277
 protein coding gene Chr1:1899440-1935543 (+)
SPRET/EiJ ENSMSPG00010013362
 protein coding gene Chr1:2401011-2439990 (+)
WSB/EiJ ENSIUOG00005010397
 protein coding gene Chr1:2122480-2162511 (+)



Homology
more
  • Human Ortholog
    TCEA1, transcription elongation factor A1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCEA1, transcription elongation factor A1
  • Synonyms
    GTF2S, SII, TCEA, TF2S, TFIIS
  • Links
    NCBI Gene ID: 6917
    UniProt: P23193

  • Chr Location
    8q11.23; chr8:53966552-54022448 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display impaired definitive erythropoiesis with loss of late stage erythroblasts, fetal liver hypoplasia, and embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    71
  • cDNA Data
    28
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033813 Ensembl Gene Model | MGI Sequence Detail 40096 C57BL/6J ±  kb
    transcript ENSMUST00000165720 Ensembl | MGI Sequence Detail 2854 Not Applicable  
    polypeptide ENSMUSP00000129157 Ensembl | MGI Sequence Detail 312 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000016157 transcription elongation factor A protein 1
      (term hierarchy)
    • InterPro Domains
      IPR035441 TFIIS/LEDGF domain superfamily
      IPR035100 Transcription elongation factor, IIS-type
      IPR003618 Transcription elongation factor S-II, central domain
      IPR036575 Transcription elongation factor S-II, central domain superfamily
      IPR006289 Transcription elongation factor, TFIIS
      IPR003617 Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type
      IPR017923 Transcription factor IIS, N-terminal
      IPR001222 Zinc finger, TFIIS-type
    • GlyGen
      P10711 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 29
      Primer pair 3
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1196623
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 5
    • Earliest
      J:33182 Hirashima S, et al., Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II. J Biol Chem. 1988 Mar 15;263(8):3858-63
    • Latest
      J:348396 Siametis A, et al., Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescence. Nat Commun. 2024 May 14;15(1):4061
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory