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Hpn Gene Detail
Summary
  • Symbol
    Hpn
  • Name
    hepsin
  • Synonyms
    Hlb320
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196620
    NCBI Gene: 15451
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30798150-30814715 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 19.30 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    264 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196620
 protein coding gene Chr7:30798150-30814751 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032061
 protein coding gene Chr7:30160778-30178869 (-)
A/J MGP_AJ_G0032038
 protein coding gene Chr7:29348095-29365302 (-)
AKR/J MGP_AKRJ_G0031971
 protein coding gene Chr7:30084456-30103423 (-)
BALB/cJ MGP_BALBcJ_G0032045
 protein coding gene Chr7:29523479-29540051 (-)
C3H/HeJ MGP_C3HHeJ_G0031762
 protein coding gene Chr7:30547765-30566694 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032511
 protein coding gene Chr7:31166842-31185556 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029561
 protein coding gene Chr7:30301434-30318456 (-)
CAST/EiJ MGP_CASTEiJ_G0031098
 protein coding gene Chr7:23804659-23821105 (-)
CBA/J MGP_CBAJ_G0031730
 protein coding gene Chr7:32627172-32643420 (-)
DBA/2J MGP_DBA2J_G0031882
 protein coding gene Chr7:29062494-29079326 (-)
FVB/NJ MGP_FVBNJ_G0031838
 protein coding gene Chr7:29180956-29197695 (-)
LP/J MGP_LPJ_G0031963
 protein coding gene Chr7:30499341-30517781 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031875
 protein coding gene Chr7:31851117-31867465 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032537
 protein coding gene Chr7:29596690-29614081 (-)
PWK/PhJ MGP_PWKPhJ_G0030820
 protein coding gene Chr7:24101750-24120861 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030657
 protein coding gene Chr7:20589292-20605908 (-)
WSB/EiJ MGP_WSBEiJ_G0031208
 protein coding gene Chr7:30004177-30021419 (-)



Homology
more
  • Human Ortholog
    HPN, hepsin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HPN, hepsin
  • Synonyms
    TMPRSS1
  • Links
    NCBI Gene ID: 3249
    neXtProt AC: NX_P05981
    UniProt: P05981

  • Chr Location
    19q13.11; chr19:35040506-35066573 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HPN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are hypothyroidic and develop profound hearing loss associated with structural changes in the tectorial membrane and a myelination defect affecting the compaction of spiral ganglion neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    77
  • cDNA Data
    77
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001249 Ensembl Gene Model | MGI Sequence Detail 16566 C57BL/6J ±  kb
    transcript ENSMUST00000039435 Ensembl | MGI Sequence Detail 1743 Not Applicable  
    polypeptide ENSMUSP00000038149 Ensembl | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 78
      Primer pair 8
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141811, MGI:2142029, MGI:3575147
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 15
    • Earliest
      J:180502 Torres-Rosado A, et al., Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7181-5
    • Latest
      J:334514 Chakraborty P, et al., Bone morphogenetic protein 2- and estradiol-17beta-induced changes in ovarian transcriptome during primordial follicle formation. Biol Reprod. 2022 Sep 12;107(3):800-812
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory