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Atp5if1 Gene Detail
Summary
  • Symbol
    Atp5if1
  • Name
    ATP synthase inhibitory factor subunit 1
  • Synonyms
    Atpif1, If1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196457
    NCBI Gene: 11983
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132257866-132260970 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 65.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    207 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196457
 protein coding gene Chr4:132257866-132262746 (-)
129S1/SvImJ ENSMUSG00200018571
 protein coding gene Chr4:125712711-125715812 (-)
A/J ENSMUSG00195035034
 protein coding gene Chr4:127037006-127040104 (-)
AKR/J ENSMUSG00220043747
 protein coding gene Chr4:126028771-126031869 (-)
BALB/cJ ENSMUSG00180040415
 protein coding gene Chr4:124670802-124673900 (-)
C3H/HeJ ENSMUSG00175040058
 protein coding gene Chr4:125683141-125686239 (-)
C57BL/6NJ ENSMUSG00215048387
 protein coding gene Chr4:127187081-127190186 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026568
 protein coding gene Chr4:122170750-122173838 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210052519
 protein coding gene Chr4:125312133-125315232 (-)
DBA/2J ENSMUSG00185048858
 protein coding gene Chr4:126844521-126847619 (-)
FVB/NJ ENSMUSG00205046626
 protein coding gene Chr4:125086213-125089311 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230035211
 protein coding gene Chr4:130651184-130654285 (-)
NOD/ShiLtJ ENSMUSG00190027074
 protein coding gene Chr4:125076833-125079931 (-)
NZO/HlLtJ ENSMUSG00225025157
 protein coding gene Chr4:136555139-136558237 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ATP5IF1, ATP synthase inhibitory factor subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATP5IF1, ATP synthase inhibitory factor subunit 1
  • Synonyms
    ATPI, ATPIF1, ATPIP, IP
  • Links
    NCBI Gene ID: 93974
    UniProt: Q9UII2

  • Chr Location
    1p35.3; chr1:28236084-28246906 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 3 alleles in 4 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knockout mice exhibit normal growth and breeding but are protected from TAC-pressure overload and isoproterenol infusion-induced cardiac hypertrophy. A different KO reduces neutrophil levels and leads to resistance to DSS-induced colitis and increased susceptibility to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    53
  • cDNA Data
    190
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054428 Ensembl Gene Model | MGI Sequence Detail 3105 C57BL/6J ±  kb
    transcript ENSMUST00000067496 Ensembl | MGI Sequence Detail 539 Not Applicable  
    polypeptide ENSMUSP00000064282 Ensembl | MGI Sequence Detail 106 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 192
      cDNA 191
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:7469630
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:44646 Yamada E, et al., Differential display analysis of murine collagen-induced arthritis: cloning of the cDNA-encoding murine ATPase inhibitor. Immunology. 1997 Dec;92(4):571-6
    • Latest
      J:357727 Brunetta HS, et al., IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat. EMBO J. 2024 Sep 16;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory