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Asic1 Gene Detail
Summary
  • Symbol
    Asic1
  • Name
    acid-sensing ion channel 1
  • Synonyms
    Accn2, ASIC, ASIC1a, ASIC1b, ASIC1 beta, ASICalpha, B530003N02Rik, BNaC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194915
    NCBI Gene: 11419
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:99568249-99599011 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.13 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    757 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194915
 protein coding gene Chr15:99568090-99599011 (+)
129S1/SvImJ ENSMUSG00200047812
 protein coding gene Chr15:96771197-96801976 (+)
A/J ENSMUSG00195035953
 protein coding gene Chr15:96637989-96668748 (+)
AKR/J ENSMUSG00220047821
 protein coding gene Chr15:96644781-96675546 (+)
BALB/cJ ENSMUSG00180035251
 protein coding gene Chr15:96546133-96578809 (+)
C3H/HeJ ENSMUSG00175039438
 protein coding gene Chr15:96817985-96848739 (+)
C57BL/6NJ ENSMUSG00215049466
 protein coding gene Chr15:96606659-96637427 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020273
 protein coding gene Chr15:93379258-93410441 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210026251
 protein coding gene Chr15:96603073-96635741 (+)
DBA/2J ENSMUSG00185035052
 protein coding gene Chr15:96651184-96681946 (+)
FVB/NJ ENSMUSG00205021922
 protein coding gene Chr15:96355641-96386410 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230038051
 protein coding gene Chr15:99994568-100025344 (+)
NOD/ShiLtJ ENSMUSG00190045888
 protein coding gene Chr15:96621434-96652168 (+)
NZO/HlLtJ ENSMUSG00225042479
 protein coding gene Chr15:100243522-100274286 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ASIC1, acid sensing ion channel subunit 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ASIC1, acid sensing ion channel subunit 1
  • Synonyms
    ACCN2, ASIC, BNaC2
  • Links
    NCBI Gene ID: 41
    UniProt: P78348

  • Chr Location
    12q13.12; chr12:50057548-50083622 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in absence of H+-gated currents in hippocampal neurons, impaired long term potentiation, reduced excitatory postsynaptic potentials, and defective spatial learning and eye blink conditioning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    73
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    24
  • cDNA Data
    37
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023017 Ensembl Gene Model | MGI Sequence Detail 30763 C57BL/6J ±  kb
    transcript ENSMUST00000228185 Ensembl | MGI Sequence Detail 1818 Not Applicable  
    polypeptide ENSMUSP00000154379 Ensembl | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 37

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2146072
    References
    more
    • Summaries
      All 175
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 21
      Phenotypes 107
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory