About   Help   FAQ
Evl Gene Detail
Summary
  • Symbol
    Evl
  • Name
    Ena-vasodilator stimulated phosphoprotein
  • Synonyms
    b2b2600Clo
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194884
    NCBI Gene: 14026
  • Alliance
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:108520979-108654775 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 59.46 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3267 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194884
protein coding gene Chr12:108520942-108654775 (+)
129S1/SvImJ ENSMUSG00200024773
protein coding gene Chr12:100293929-100427732 (+)
A/J ENSMUSG00195042733
protein coding gene Chr12:102854606-102988874 (+)
AKR/J ENSMUSG00220036200
protein coding gene Chr12:100731972-100860042 (+)
BALB/cJ ENSMUSG00180044151
protein coding gene Chr12:102057036-102190844 (+)
C3H/HeJ ENSMUSG00175031846
protein coding gene Chr12:104671512-104799571 (+)
C57BL/6NJ ENSMUSG00215038754
protein coding gene Chr12:101329965-101463756 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018103
protein coding gene Chr12:103024009-103148632 (+)
CAST/EiJ ENSTCUG00005017938
protein coding gene Chr12:100814429-100941952 (+)
CBA/J ENSMUSG00210014361
protein coding gene Chr12:101733124-101861188 (+)
DBA/2J ENSMUSG00185026992
protein coding gene Chr12:103514805-103648399 (+)
FVB/NJ ENSMUSG00205012175
protein coding gene Chr12:100738147-100878748 (+)
JF1/MsJ ENSUMUG00000015571
protein coding gene Chr12:108275418-108404016 (+)
LP/J ENSMUSG00230026543
protein coding gene Chr12:110558886-110692684 (+)
NOD/ShiLtJ ENSMUSG00190020735
protein coding gene Chr12:84353959-84482019 (-)
NZO/HlLtJ ENSMUSG00225036776
protein coding gene Chr12:112311215-112451806 (+)
PWK/PhJ ENSLUMG00010044253
protein coding gene Chr12:101754109-101882315 (+)
SPRET/EiJ ENSMSPG00010015689
protein coding gene Chr12:104040709-104174016 (+)
WSB/EiJ ENSIUOG00005007669
protein coding gene Chr12:100745144-100878987 (+)



Homology
more
  • Human Ortholog
    EVL, Enah/Vasp-like
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EVL, Enah/Vasp-like
  • Synonyms
    RNB6
  • Links
    NCBI Gene ID: 51466
    UniProt: Q9UI08

  • Chr Location
    14q32.2; chr14:99971422-100144236 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotypes from multigenic genotypes
    9 images
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable with no apparent defects in gross morphology or histology. Mice homozygous for a different knock-out allele are viable and fertile but display defects in monocyte migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021262 Ensembl Gene Model | MGI Sequence Detail 133797 C57BL/6J ±  kb
    transcript ENSMUST00000223109 Ensembl | MGI Sequence Detail 1487 Not Applicable  
    polypeptide ENSMUSP00000152364 Ensembl | MGI Sequence Detail 426 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 101
      cDNA 101
      Antibodies 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144857, MGI:5560789
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 10
      Gene Ontology 12
      Phenotypes 21
    • Earliest
      J:44192 Gertler FB, et al., Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996 Oct 18;87(2):227-39
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory