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Thbs4 Gene Detail
Summary
  • Symbol
    Thbs4
  • Name
    thrombospondin 4
  • Synonyms
    TSP-4, TSP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101779
    NCBI Gene: 21828
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:92888098-92931326 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 47.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1344 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101779
 protein coding gene Chr13:92888094-92931326 (-)
129S1/SvImJ ENSMUSG00200008485
 protein coding gene Chr13:87385148-87428374 (-)
A/J ENSMUSG00195023377
 protein coding gene Chr13:87892177-87935671 (-)
AKR/J ENSMUSG00220013408
 protein coding gene Chr13:86365819-86409050 (-)
BALB/cJ ENSMUSG00180015650
 protein coding gene Chr13:88421406-88464635 (-)
C3H/HeJ ENSMUSG00175022746
 protein coding gene Chr13:88585334-88628561 (-)
C57BL/6NJ ENSMUSG00215002966
 protein coding gene Chr13:88485673-88528900 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018774
 protein coding gene Chr13:86505469-86548941 (-)
CAST/EiJ ENSTCUG00005009528
 protein coding gene Chr13:87695698-87739305 (-)
CBA/J ENSMUSG00210024374
 protein coding gene Chr13:87881746-87924987 (-)
DBA/2J ENSMUSG00185017671
 protein coding gene Chr13:91567797-91611024 (-)
FVB/NJ ENSMUSG00205008325
 protein coding gene Chr13:87377336-87420566 (-)
JF1/MsJ ENSUMUG00000016794
 protein coding gene Chr13:91294059-91337339 (-)
LP/J ENSMUSG00230032129
 protein coding gene Chr13:101585882-101629106 (-)
NOD/ShiLtJ ENSMUSG00190018298
 protein coding gene Chr13:88268122-88311354 (-)
NZO/HlLtJ ENSMUSG00225033393
 protein coding gene Chr13:94099514-94142740 (-)
PWK/PhJ ENSLUMG00010011022
 protein coding gene Chr13:87397692-87441105 (-)
SPRET/EiJ ENSMSPG00010006309
 protein coding gene Chr13:88613882-88657747 (-)
WSB/EiJ ENSIUOG00005030915
 protein coding gene Chr13:87288650-87331893 (-)



Homology
more
  • Human Ortholog
    THBS4, thrombospondin 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THBS4, thrombospondin 4
  • Synonyms
    TSP-4, TSP4
  • Links
    NCBI Gene ID: 7060
    UniProt: P35443

  • Chr Location
    5q14.1; chr5:79991311-80083831 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit increased sensitivity to cardiac pressure overload, including increased hypertrophy, decreased ejection fraction, decreased microvessel number, increased extracellular matrix deposition and increased fibrosis. Homozygous KO leads to impaired wound healing and delayed retinal vasculature development and affects macrophage differentiation. Homozygosity for the p.A389P mutation leads to enhanced wound healing and accelerated retinal vasculature development and affects macrophage differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    944
  • Tissues
    92
  • cDNA Data
    35
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021702 Ensembl Gene Model | MGI Sequence Detail 43229 C57BL/6J ±  kb
    transcript ENSMUST00000022213 Ensembl | MGI Sequence Detail 3198 Not Applicable  
    polypeptide ENSMUSP00000022213 Ensembl | MGI Sequence Detail 963 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 37
      Primer pair 2
      Other 1
      Antibodies 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 20
      Gene Ontology 13
      Phenotypes 39
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:364942 Hasel P, et al., Defining the molecular identity and morphology of glia limitans superficialis astrocytes in vertebrates. Cell Rep. 2025 Mar 25;44(3):115344
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory