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Bmx Gene Detail
Summary
  • Symbol
    Bmx
  • Name
    BMX non-receptor tyrosine kinase
  • Synonyms
    Etk, Etk/Bmx, Tyro8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101778
    NCBI Gene: 12169
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:162975838-163041189 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 76.12 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1506 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101778
 protein coding gene ChrX:162975838-163041189 (-)
129S1/SvImJ ENSMUSG00200024289
 protein coding gene ChrX:139697858-139763320 (-)
A/J ENSMUSG00195016145
 protein coding gene ChrX:144818444-144883922 (-)
AKR/J ENSMUSG00220028994
 protein coding gene ChrX:136697278-136762752 (-)
BALB/cJ ENSMUSG00180037969
 protein coding gene ChrX:140208171-140273658 (-)
C3H/HeJ ENSMUSG00175010275
 protein coding gene ChrX:144753962-144819421 (-)
C57BL/6NJ ENSMUSG00215021510
 protein coding gene ChrX:140594039-140659526 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033559
 protein coding gene ChrX:152497564-152560311 (-)
CAST/EiJ ENSTCUG00005023323
 protein coding gene ChrX:142311618-142378163 (-)
CBA/J ENSMUSG00210028711
 protein coding gene ChrX:142096200-142161656 (-)
DBA/2J ENSMUSG00185029701
 protein coding gene ChrX:157024864-157090328 (-)
FVB/NJ ENSMUSG00205025532
 protein coding gene ChrX:140682035-140747519 (-)
JF1/MsJ ENSUMUG00000028464
 protein coding gene ChrX:177438611-177504937 (-)
LP/J ENSMUSG00230024871
 protein coding gene ChrX:163814781-163880251 (-)
NOD/ShiLtJ ENSMUSG00190029824
 protein coding gene ChrX:141200892-141266353 (-)
NZO/HlLtJ ENSMUSG00225038575
 protein coding gene ChrX:167203207-167268612 (-)
PWK/PhJ ENSLUMG00010039802
 protein coding gene ChrX:138514231-138580669 (-)
SPRET/EiJ ENSMSPG00010025463
 protein coding gene ChrX:143740141-143804783 (-)
WSB/EiJ ENSIUOG00005024726
 protein coding gene ChrX:141642842-141709958 (-)



Homology
more
  • Human Ortholog
    BMX, BMX non-receptor tyrosine kinase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMX, BMX non-receptor tyrosine kinase
  • Synonyms
    ETK, PSCTK2, PSCTK3
  • Links
    NCBI Gene ID: 660
    UniProt: P51813

  • Chr Location
    Xp22.2; chrX:15464246-15556529 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation are fertile and have a normal life span but are protected from arthritis in a passive transfer model.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    829
  • Tissues
    142
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12169 NCBI Gene Model | MGI Sequence Detail 65352 C57BL/6J ±  kb
    transcript NM_009759 RefSeq | MGI Sequence Detail 3005 C57BL/6  
    polypeptide P97504 UniProt | EBI | MGI Sequence Detail 651 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 1
      cDNA 20
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38318, MGI:109273
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 24
    • Earliest
      J:36874 Rinke de Wit TF, et al., Expression of tyrosine kinase gene in mouse thymic stromal cells. Int Immunol. 1996 Nov;8(11):1787-95
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory