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Pja1 Gene Detail
Summary
  • Symbol
    Pja1
  • Name
    praja ring finger ubiquitin ligase 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101765
    NCBI Gene: 18744
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:98509340-98514874 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 43.38 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101765
 protein coding gene ChrX:98509340-98514879 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035936
 protein coding gene ChrX:95897907-95903421 (-)
A/J MGP_AJ_G0035921
 protein coding gene ChrX:95948701-95954216 (-)
AKR/J MGP_AKRJ_G0035837
 protein coding gene ChrX:98697528-98703057 (-)
BALB/cJ MGP_BALBcJ_G0035904
 protein coding gene ChrX:94723215-94728722 (-)
C3H/HeJ MGP_C3HHeJ_G0035613
 protein coding gene ChrX:96338837-96344337 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036433
 protein coding gene ChrX:98821897-98829009 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033263
 protein coding gene ChrX:93778192-93783636 (-)
CAST/EiJ MGP_CASTEiJ_G0034900
 protein coding gene ChrX:80668250-80673742 (-)
CBA/J MGP_CBAJ_G0035588
 protein coding gene ChrX:101855728-101861326 (-)
DBA/2J MGP_DBA2J_G0035742
 protein coding gene ChrX:95189501-95195034 (-)
FVB/NJ MGP_FVBNJ_G0035680
 protein coding gene ChrX:94584096-94589594 (-)
LP/J MGP_LPJ_G0035832
 protein coding gene ChrX:96906029-96911573 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035715
 protein coding gene ChrX:106338213-106343718 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036460
 protein coding gene ChrX:95636909-95642426 (-)
PWK/PhJ MGP_PWKPhJ_G0034599
 protein coding gene ChrX:78305498-78311057 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034427
 protein coding gene ChrX:81530389-81535528 (-)
WSB/EiJ MGP_WSBEiJ_G0035039
 protein coding gene ChrX:94363424-94368944 (-)



Homology
more
  • Human Ortholog
    PJA1, praja ring finger ubiquitin ligase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PJA1, praja ring finger ubiquitin ligase 1
  • Synonyms
    PRAJA1, RNF70
  • Links
    NCBI Gene ID: 64219
    neXtProt AC: NX_Q8NG27
    UniProt: Q8NG27

  • Chr Location
    Xq13.1; chrX:69160746-69165521 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice harboring an ENU-induced mutation show no detectable phenotypic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    817
  • Tissues
    78
  • cDNA Data
    131
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18744 NCBI Gene Model | MGI Sequence Detail 5535 C57BL/6J ±  kb
    transcript NM_001290555 RefSeq | MGI Sequence Detail 2947 C57BL/6  
    polypeptide O55176 UniProt | EBI | MGI Sequence Detail 578 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 132
      cDNA 132

      Microarray probesets 7
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 7
      Gene Ontology 4
      Phenotypes 6
    • Earliest
      J:44194 Mishra L, et al., Praja1, a novel gene encoding a RING-H2 motif in mouse development. Oncogene. 1997 Nov 6;15(19):2361-8
    • Latest
      J:341589 Wang X, et al., PJA1 mediates the effects of astrocytic GPR30 on learning and memory in female mice. J Clin Invest. 2023 Sep 15;133(18)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory