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Klf10 Gene Detail
Summary
  • Symbol
    Klf10
  • Name
    Kruppel-like transcription factor 10
  • Synonyms
    Egral, Gdnfif, mGIF, Tieg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101353
    NCBI Gene: 21847
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:38291707-38300950 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    208 from dbSNP Build 142
  • Strain Annotations
    20
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101353
 protein coding gene Chr15:38291702-38300950 (-)
129S1/SvImJ ENSMUSGG00200054756
 protein coding gene Chr15:35297248-35300684 (-)
A/J ENSMUSGG00195055259
 protein coding gene Chr15:35221319-35224755 (-)
AKR/J ENSMUSGG00220054779
 protein coding gene Chr15:35135212-35138648 (-)
BALB/cJ ENSMUSGG00180055349
 protein coding gene Chr15:35201796-35205232 (-)
C3H/HeJ ENSMUSGG00175054932
 protein coding gene Chr15:35400489-35403925 (-)
C57BL/6NJ ENSMUSGG00215055527
 protein coding gene Chr15:35208313-35211749 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019750
 protein coding gene Chr15:33163163-33169527 (-)
CAST/EiJ ENSTCUGG00005054444
 protein coding gene Chr15:35223873-35227308 (-)
CBA/J ENSMUSGG00210054858
 protein coding gene Chr15:35314843-35318279 (-)
DBA/2J ENSMUSG00185031465
 protein coding gene Chr15:35301157-35301989 (-)
DBA/2J ENSMUSGG00185057340
 protein coding gene Chr15:35295699-35299135 (-)
FVB/NJ ENSMUSGG00205054097
 protein coding gene Chr15:35187728-35191164 (-)
JF1/MsJ ENSUMUGG00000058454
 protein coding gene Chr15:35196540-35199970 (-)
LP/J ENSMUSGG00230055293
 protein coding gene Chr15:38678305-38681741 (-)
NOD/ShiLtJ ENSMUSGG00190055070
 protein coding gene Chr15:35265275-35268711 (-)
NZO/HlLtJ ENSMUSGG00225055439
 protein coding gene Chr15:38987105-38990541 (-)
PWK/PhJ ENSLUMGG00010054168
 protein coding gene Chr15:35345423-35348861 (-)
SPRET/EiJ ENSMSPG00010012042
 protein coding gene Chr15:36007442-36016030 (-)
WSB/EiJ ENSIUOGG00005053928
 protein coding gene Chr15:35314466-35317902 (-)



Homology
more
  • Human Ortholog
    KLF10, KLF transcription factor 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF10, KLF transcription factor 10
  • Synonyms
    EGRA, EGR-alpha, TIEG, TIEG1
  • Links
    NCBI Gene ID: 7071
    UniProt: Q13118

  • Chr Location
    8q22.3; chr8:102648783-102655728 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants display increased osteoblast formation and impaired osteoblast function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    920
  • Tissues
    154
  • cDNA Data
    74
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037465 Ensembl Gene Model | MGI Sequence Detail 9244 C57BL/6J ±  kb
    transcript ENSMUST00000074043 Ensembl | MGI Sequence Detail 3044 Not Applicable  
    polypeptide ENSMUSP00000073690 Ensembl | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 1
      cDNA 77
      Primer pair 6
      Other 1
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36079, MGI:107509, MGI:2145945
    References
    more
    • Summaries
      All 127
      Developmental Gene Expression 14
      Gene Ontology 11
      Phenotypes 61
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:364033 Garduno-Tamayo NA, et al., Klf10 Regulates the Emergence of Glial Phenotypes During Hypothalamic Development. J Neurosci Res. 2025 Feb;103(2):e70020
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory