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Klf10 Gene Detail
Summary
  • Symbol
    Klf10
  • Name
    Kruppel-like transcription factor 10
  • Synonyms
    Egral, Gdnfif, mGIF, Tieg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101353
    NCBI Gene: 21847
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:38291707-38300950 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 15.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101353
 protein coding gene Chr15:38291702-38300950 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021807
 protein coding gene Chr15:36814257-36820537 (-)
A/J MGP_AJ_G0021767
 protein coding gene Chr15:35384522-35391781 (-)
AKR/J MGP_AKRJ_G0021748
 protein coding gene Chr15:36445108-36451411 (-)
BALB/cJ MGP_BALBcJ_G0021774
 protein coding gene Chr15:35423330-35429653 (-)
C3H/HeJ MGP_C3HHeJ_G0021548
 protein coding gene Chr15:36371300-36378533 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022213
 protein coding gene Chr15:38234675-38241422 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019750
 protein coding gene Chr15:33163163-33169527 (-)
CAST/EiJ MGP_CASTEiJ_G0021065
 protein coding gene Chr15:36797749-36803839 (-)
CBA/J MGP_CBAJ_G0021517
 protein coding gene Chr15:39457103-39466609 (-)
DBA/2J MGP_DBA2J_G0021641
 protein coding gene Chr15:35222040-35228152 (-)
FVB/NJ MGP_FVBNJ_G0021619
 protein coding gene Chr15:34625607-34631886 (-)
LP/J MGP_LPJ_G0021711
 protein coding gene Chr15:36661005-36667288 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021643
 protein coding gene Chr15:42460612-42466456 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022236
 protein coding gene Chr15:36569122-36575352 (-)
PWK/PhJ MGP_PWKPhJ_G0020809
 protein coding gene Chr15:35276890-35283198 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020647
 protein coding gene Chr15:36261910-36268223 (-)
WSB/EiJ MGP_WSBEiJ_G0021120
 protein coding gene Chr15:36519467-36527167 (-)



Homology
more
  • Human Ortholog
    KLF10, KLF transcription factor 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLF10, KLF transcription factor 10
  • Synonyms
    EGRA, EGR-alpha, TIEG, TIEG1
  • Links
    NCBI Gene ID: 7071
    neXtProt AC: NX_Q13118
    UniProt: Q13118

  • Chr Location
    8q22.3; chr8:102648784-102655725 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants display increased osteoblast formation and impaired osteoblast function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    934
  • Tissues
    116
  • cDNA Data
    74
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037465 Ensembl Gene Model | MGI Sequence Detail 9244 C57BL/6J ±  kb
    transcript ENSMUST00000074043 Ensembl | MGI Sequence Detail 3044 Not Applicable  
    polypeptide ENSMUSP00000073690 Ensembl | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      Genomic 1
      cDNA 77
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36079, MGI:107509, MGI:2145945
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 14
      Gene Ontology 10
      Phenotypes 58
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:339625 Hwang S, et al., KLF10 Inhibits TGF-beta-Mediated Activation of Hepatic Stellate Cells via Suppression of ATF3 Expression. Int J Mol Sci. 2023 Aug 9;24(16)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory