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Ifit3 Gene Detail
Summary
  • Symbol
    Ifit3
  • Name
    interferon-induced protein with tetratricopeptide repeats 3
  • Synonyms
    Ifi49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101055
    NCBI Gene: 15959
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:34560931-34566131 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 29.74 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    69 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101055
 protein coding gene Chr19:34560519-34566382 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025062
 protein coding gene Chr19:33367111-33368778 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0025005
 protein coding gene Chr19:32840163-32841833 (+)
BALB/cJ MGP_BALBcJ_G0025035
 protein coding gene Chr19:31848258-31849928 (+)
C3H/HeJ MGP_C3HHeJ_G0024793
 protein coding gene Chr19:32914847-32919832 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025476
 protein coding gene Chr19:34317754-34321276 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022895
 protein coding gene Chr19:31165457-31170657 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0024771
 protein coding gene Chr19:35948653-35950320 (+)
DBA/2J MGP_DBA2J_G0024902
 protein coding gene Chr19:31621033-31622700 (+)
FVB/NJ MGP_FVBNJ_G0024865
 protein coding gene Chr19:31476062-31481233 (+)
LP/J MGP_LPJ_G0024989
 protein coding gene Chr19:33447527-33449194 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024894
 protein coding gene Chr19:35708893-35728647 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025534
 protein coding gene Chr19:32910021-32916295 (+)
PWK/PhJ MGP_PWKPhJ_G0024012
 protein coding gene Chr19:31423596-31425366 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023814
 protein coding gene Chr19:31750219-31755416 (+)
WSB/EiJ MGP_WSBEiJ_G0024328
 protein coding gene Chr19:32997501-32999171 (+)



Homology
more
  • Human Ortholog
    IFIT3, interferon induced protein with tetratricopeptide repeats 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFIT3, interferon induced protein with tetratricopeptide repeats 3
  • Synonyms
    cig41, CIG-49, GARG-49, IFI60, IFIT4, IRG2, ISG60, P60, RIG-G
  • Links
    NCBI Gene ID: 3437
    neXtProt AC: NX_O14879
    UniProt: O14879

  • Chr Location
    10q23.31; chr10:89327307-89377473 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    814
  • Tissues
    98
  • cDNA Data
    33
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074896 Ensembl Gene Model | MGI Sequence Detail 5201 C57BL/6J ±  kb
    transcript ENSMUST00000102825 Ensembl | MGI Sequence Detail 1745 Not Applicable  
    polypeptide ENSMUSP00000099889 Ensembl | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 33
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 3
    • Earliest
      J:18633 Lee CG, et al., Molecular cloning and characterization of a murine LPS-inducible cDNA. J Immunol. 1994 Jun 15;152(12):5758-67
    • Latest
      J:320348 Aditi, et al., Genome instability independent of type I interferon signaling drives neuropathology caused by impaired ribonucleotide excision repair. Neuron. 2021 Dec 15;109(24):3962-3979.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory