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Plagl1 Gene Detail
Summary
  • Symbol
    Plagl1
  • Name
    pleiomorphic adenoma gene-like 1
  • Synonyms
    Zac1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100874
    NCBI Gene: 22634
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:12966576-13007438 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 4.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1037 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100874
 protein coding gene Chr10:12936248-13007438 (+)
129S1/SvImJ ENSMUSG00200009886
 protein coding gene Chr10:9942922-10014081 (+)
A/J ENSMUSG00195009852
 protein coding gene Chr10:9869191-9940303 (+)
AKR/J ENSMUSG00220007425
 protein coding gene Chr10:9965789-10036967 (+)
BALB/cJ ENSMUSG00180014791
 protein coding gene Chr10:10026135-10097263 (+)
C3H/HeJ ENSMUSG00175019113
 protein coding gene Chr10:10022403-10093507 (+)
C57BL/6NJ ENSMUSG00215005119
 protein coding gene Chr10:9887103-9958307 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015121
 protein coding gene Chr10:9340047-9410303 (+)
CAST/EiJ ENSTCUG00005017494
 protein coding gene Chr10:9883272-9954666 (+)
CBA/J ENSMUSG00210012367
 protein coding gene Chr10:9972182-10043281 (+)
DBA/2J ENSMUSG00185009773
 protein coding gene Chr10:10001316-10072975 (+)
FVB/NJ ENSMUSG00205014187
 protein coding gene Chr10:10064344-10135514 (+)
JF1/MsJ ENSUMUG00000010363
 protein coding gene Chr10:10043616-10115241 (+)
LP/J ENSMUSG00230016935
 protein coding gene Chr10:11625509-11696612 (+)
NOD/ShiLtJ ENSMUSG00190023954
 protein coding gene Chr10:9998619-10069794 (+)
NZO/HlLtJ ENSMUSG00225015711
 protein coding gene Chr10:16129315-16200475 (+)
PWK/PhJ ENSLUMG00010019512
 protein coding gene Chr10:9797328-9868920 (+)
SPRET/EiJ ENSMSPG00010010716
 protein coding gene Chr10:10251723-10270492 (+)
WSB/EiJ ENSIUOG00005012805
 protein coding gene Chr10:9600683-9672458 (+)



Homology
more
  • Human Ortholog
    PLAGL1, PLAG1 like zinc finger 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLAGL1, PLAG1 like zinc finger 1
  • Synonyms
    LOT1, ZAC, ZAC1
  • Links
    NCBI Gene ID: 5325
    UniProt: Q9UM63

  • Chr Location
    6q24.2; chr6:143940300-144064714 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 2 alleles in 3 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit significantly reduced birth weights. Heterozygous mice with a paternal copy of the null allele show reduced fetal and birth weights, altered ossification, dyspnea and background-dependent neonatal lethality, as well as wrinkled skin and curly tails with 30% penetrance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1482
  • Tissues
    433
  • cDNA Data
    71
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22634 NCBI Gene Model | MGI Sequence Detail 40863 C57BL/6J ±  kb
    transcript NM_009538 RefSeq | MGI Sequence Detail 5235 ZRU/MplStud  
    polypeptide NP_033564 RefSeq | MGI Sequence Detail 704 ZRU/MplStud  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    • GlyGen
      Q9JLQ4 2 sites
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 71
      Primer pair 15
      Other 8
      Antibodies 3

      Microarray probesets 5
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 60
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:40765 Spengler D, et al., Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain. EMBO J. 1997 May 15;16(10):2814-25
    • Latest
      J:382973 Lin DH, et al., mRNA 3' UTRs direct microRNA degradation to participate in imprinted gene networks and regulate growth. Genes Dev. 2026 Apr 1;40(7-8):586-603
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory